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29 results

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Page 1
Enzyme activity analysis of CYP2C18 with exon 5 skipped.
Zhu-Ge J, Yu YN. Zhu-Ge J, et al. Acta Pharmacol Sin. 2004 Aug;25(8):1065-9. Acta Pharmacol Sin. 2004. PMID: 15301741 Free article.
AIM: To study the enzyme activity of CYP2C18 variant with exon 5 skipped. METHODS: A full length CYP2C18 cDNA X1 and an exon 5 skipped variant CYP2C18 X2 were separately subcloned into mammalian expression vector pREP9 to transfect HepG2 cells. ...The cytotox …
AIM: To study the enzyme activity of CYP2C18 variant with exon 5 skipped. METHODS: A full length CYP2C18 cDNA X1 and an exon 5 …
Cytochrome P450 gene polymorphism and cancer.
Agundez JA. Agundez JA. Curr Drug Metab. 2004 Jun;5(3):211-24. doi: 10.2174/1389200043335621. Curr Drug Metab. 2004. PMID: 15180491 Review.
Consistent evidences for association between CYP polymorphisms and lung, head and neck, and liver cancer were reported. Controversial findings suggest that colorectal and prostate cancers may be associated to CYP polymorphisms, whereas no evidences for a relevant as …
Consistent evidences for association between CYP polymorphisms and lung, head and neck, and liver cancer were reported. Controversial …
Anti-Cancer Prodrug Cyclophosphamide Exerts Thrombogenic Effects on Human Venous Endothelial Cells Independent of CYP450 Activation-Relevance to Thrombosis.
Krüger-Genge A, Köhler S, Laube M, Haileka V, Lemm S, Majchrzak K, Kammerer S, Schulz C, Storsberg J, Pietzsch J, Küpper JH, Jung F. Krüger-Genge A, et al. Cells. 2023 Jul 29;12(15):1965. doi: 10.3390/cells12151965. Cells. 2023. PMID: 37566045 Free PMC article.
Cancer patients are at a very high risk of serious thrombotic events, often fatal. The causes discussed include the detachment of thrombogenic particles from tumor cells or the adverse effects of chemotherapeutic agents. ...No expression of CYP2B6, CYP3A4, CYP2C9 and CYP2C …
Cancer patients are at a very high risk of serious thrombotic events, often fatal. The causes discussed include the detachment of thr …
Identification of New Potential Targets for Pancreatic Ductal Adenocarcinoma by Integrated Bioinformatic Analysis.
Li R, Yang T, Ren KE, Li J, Nagakawa Y, Zeng Y, Natsuyama Y, Yi SQ. Li R, et al. Anticancer Res. 2024 Oct;44(10):4233-4250. doi: 10.21873/anticanres.17254. Anticancer Res. 2024. PMID: 39348994
BACKGROUND/AIM: Pancreatic cancer is the fourth leading cause of cancer-related death in both men and women worldwide. ...LPAR5, CYP2C18, SERPINH1 and ACSL5 were markedly upregulated in stage IV PDAC. LPAR5, CYP2C18, SERPINH1 and ACSL5 were upregulated …
BACKGROUND/AIM: Pancreatic cancer is the fourth leading cause of cancer-related death in both men and women worldwide. ...LPAR …
Development of a new assay system for bladder cancer using interactions between cytochromes P450 and serum.
Kuwada H, Ihara K, Imaishi H. Kuwada H, et al. Drug Metab Pharmacokinet. 2022 Dec;47:100472. doi: 10.1016/j.dmpk.2022.100472. Epub 2022 Aug 17. Drug Metab Pharmacokinet. 2022. PMID: 36242895
To overcome bladder cancer, one of the most common cancer and deadly cancers in the world, early diagnosis and treatment interventions are crucial. ...When assays were performed using sera recovered from mice with bladder cancer and control mice, signi …
To overcome bladder cancer, one of the most common cancer and deadly cancers in the world, early diagnosis and treatmen …
Integrated bioinformatics analysis and experimental validation to understand tryptophan metabolism-related genes in hepatocellular carcinoma.
Chen H, Sun W, Xie M, Li Z, Chen B, Zhang T, Lv L, Wang L, Lu L, Tang Q, Luo L. Chen H, et al. J Cancer. 2024 Jul 16;15(15):4879-4892. doi: 10.7150/jca.91306. eCollection 2024. J Cancer. 2024. PMID: 39132147 Free PMC article.
Results: Trp metabolism-related DECs for HCCs were obtained, including MAOB, CYP1A2, KYNU, CYP2E1, ALDH2, CYP2C18, TDO2, AOX1, CYP3A4 and INMT. Moreover, multivariate COX regression results showed that ALDH2 can serve as an independent prognostic molecule and its transcrip …
Results: Trp metabolism-related DECs for HCCs were obtained, including MAOB, CYP1A2, KYNU, CYP2E1, ALDH2, CYP2C18, TDO2, AOX1, CYP3A4 …
Association of breast cancer risk with polymorphisms in genes involved in the metabolism of xenobiotics and interaction with tobacco smoking: A gene-set analysis.
Berrandou T, Mulot C, Cordina-Duverger E, Arveux P, Laurent-Puig P, Truong T, Guénel P. Berrandou T, et al. Int J Cancer. 2019 Apr 15;144(8):1896-1908. doi: 10.1002/ijc.31917. Epub 2018 Dec 14. Int J Cancer. 2019. PMID: 30303517
We used a gene-set analysis method to study the association between breast cancer risk and genetic variation in XM genes (seen as a set of SNPs) and in the XM pathway (seen as a set of genes). ...Genetic variation in the whole XM pathway was significantly associated with p …
We used a gene-set analysis method to study the association between breast cancer risk and genetic variation in XM genes (seen as a s …
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis.
Hu K, Chen F. Hu K, et al. Genet Mol Biol. 2012 Jul;35(3):701-8. doi: 10.1590/S1415-47572012005000045. Epub 2012 Jul 13. Genet Mol Biol. 2012. PMID: 23055812 Free PMC article.
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. ...The genes in these pathways, e.g., ZAP70, …
Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulator …
Development of a Clinical Prognostic Model for Metabolism-Related Genes in Squamous Lung Cancer and Correlation Analysis of Immune Microenvironment.
Zhuang Z, Gao C. Zhuang Z, et al. Biomed Res Int. 2022 Sep 6;2022:6962056. doi: 10.1155/2022/6962056. eCollection 2022. Biomed Res Int. 2022. PMID: 36110123 Free PMC article.
BACKGROUND: The incidence of squamous lung cancer (LUSC) has substantially increased. Systematic studies of metabolic genomic patterns are fundamental for the treatment and prediction of LUSC. Because cancer metabolism and immune cell metabolism have been studied in …
BACKGROUND: The incidence of squamous lung cancer (LUSC) has substantially increased. Systematic studies of metabolic genomic pattern …
Revisiting an Expression Dataset of Discordant Inflammatory Bowel Disease Twin Pairs Using a Mutation Burden Test Reveals CYP2C18 as a Novel Marker.
Du J, Yin J, Du H, Zhang J. Du J, et al. Front Genet. 2021 Jun 15;12:680125. doi: 10.3389/fgene.2021.680125. eCollection 2021. Front Genet. 2021. PMID: 34211502 Free PMC article.
Finally, by combining these expression features with genetic resources, we identified some candidate genes with potential to serve as novel markers of ulcerative colitis, such as CYP2C18. Ulcerative colitis is a subtype of inflammatory bowel disease and a polygenic disorde …
Finally, by combining these expression features with genetic resources, we identified some candidate genes with potential to serve as novel …
29 results