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CYP2D6 phenotypes are associated with adverse outcomes related to opioid medications.
St Sauver JL, Olson JE, Roger VL, Nicholson WT, Black JL 3rd, Takahashi PY, Caraballo PJ, Bell EJ, Jacobson DJ, Larson NB, Bielinski SJ. St Sauver JL, et al. Pharmgenomics Pers Med. 2017 Jul 24;10:217-227. doi: 10.2147/PGPM.S136341. eCollection 2017. Pharmgenomics Pers Med. 2017. PMID: 28769582 Free PMC article.
Therefore, we examined the association between CYP2D6 phenotype and poor pain control or other adverse symptoms related to the use of opioids in a sample of primary care patients. ...We reviewed the electronic health record of these patie …
Therefore, we examined the association between CYP2D6 phenotype and poor pain control or other adverse symptoms …
Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics.
Lopes GS, Bielinski SJ, Moyer AM, Black Iii JL, Jacobson DJ, Jiang R, Larson NB, St Sauver JL. Lopes GS, et al. Pharmgenomics Pers Med. 2020 Mar 13;13:71-79. doi: 10.2147/PGPM.S239222. eCollection 2020. Pharmgenomics Pers Med. 2020. PMID: 32214840 Free PMC article.
We used a large sample of patients to study associations between CYP2D6 phenotypes and estimated CYP2D6 enzymatic activity scores with pain control and adverse reactions related to codeine and tramadol use. ...Opioid-related …
We used a large sample of patients to study associations between CYP2D6 phenotypes and estimated CYP2D6 enzymati …
Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
Reizine N, Danahey K, Schierer E, Liu P, Middlestadt M, Ludwig J, Truong TM, van Wijk XMR, Yeo KJ, Malec M, Ratain MJ, O'Donnell PH. Reizine N, et al. Oncologist. 2021 Nov;26(11):e2042-e2052. doi: 10.1002/onco.13953. Epub 2021 Sep 19. Oncologist. 2021. PMID: 34423496 Free PMC article.
This study showed that patients with cancer frequently receive CYP2D6-dependent opioids. However, patients with CYP2D6 intermediate and poor metabolizer status had increased numbers of pain-related hospitalizations and more frequently required the pote …
This study showed that patients with cancer frequently receive CYP2D6-dependent opioids. However, patients with CYP2D6 …