Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S.
Sociali G, et al. Among authors: caffa i.
FASEB J. 2017 Jul;31(7):3138-3149. doi: 10.1096/fj.201601294R. Epub 2017 Apr 6.
FASEB J. 2017.
PMID: 28386046
Free PMC article.
We took advantage of a recently identified SIRT6 inhibitor, compound 1, to study the effect of pharmacological Sirt6 inhibition in a mouse model of T2DM (i.e., in high-fat-diet-fed animals). The administration of the Sirt6 inhibitor for 10 d was well tolerated and improved …
We took advantage of a recently identified SIRT6 inhibitor, compound 1, to study the effect of pharmacological Sirt6 inhibition in a mouse m …