Caflisch A - Search Results

1

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.

Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W. Lee JH, et al. Among authors: caflisch a. Mol Cell. 2021 Aug 19;81(16):3368-3385.e9. doi: 10.1016/j.molcel.2021.07.024. Epub 2021 Aug 9. Mol Cell. 2021. PMID: 34375583 Free PMC article.

2

Flexible Binding of m⁶A Reader Protein YTHDC1 to Its Preferred RNA Motif.

Li Y, Bedi RK, Wiedmer L, Huang D, Śledź P, Caflisch A. Li Y, et al. Among authors: caflisch a. J Chem Theory Comput. 2019 Dec 10;15(12):7004-7014. doi: 10.1021/acs.jctc.9b00987. Epub 2019 Nov 14. J Chem Theory Comput. 2019. PMID: 31670957

3

Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.

Li Y, Bedi RK, Moroz-Omori EV, Caflisch A. Li Y, et al. Among authors: caflisch a. J Chem Inf Model. 2020 Dec 28;60(12):5932-5935. doi: 10.1021/acs.jcim.0c01029. Epub 2020 Oct 19. J Chem Inf Model. 2020. PMID: 33073985

4

METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes.

Moroz-Omori EV, Huang D, Kumar Bedi R, Cheriyamkunnel SJ, Bochenkova E, Dolbois A, Rzeczkowski MD, Li Y, Wiedmer L, Caflisch A. Moroz-Omori EV, et al. Among authors: caflisch a. ChemMedChem. 2021 Oct 6;16(19):3035-3043. doi: 10.1002/cmdc.202100291. Epub 2021 Jul 29. ChemMedChem. 2021. PMID: 34237194 Free PMC article.

5

Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir.

Pohl MO, Busnadiego I, Marrafino F, Wiedmer L, Hunziker A, Fernbach S, Glas I, Moroz-Omori EV, Hale BG, Caflisch A, Stertz S. Pohl MO, et al. Among authors: caflisch a. J Gen Virol. 2021 Jul;102(7):001625. doi: 10.1099/jgv.0.001625. J Gen Virol. 2021. PMID: 34319869 Free PMC article.

6

1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.

Dolbois A, Bedi RK, Bochenkova E, Müller A, Moroz-Omori EV, Huang D, Caflisch A. Dolbois A, et al. Among authors: caflisch a. J Med Chem. 2021 Sep 9;64(17):12738-12760. doi: 10.1021/acs.jmedchem.1c00773. Epub 2021 Aug 25. J Med Chem. 2021. PMID: 34431664 Free article.

7

A Reader-Based Assay for m⁶A Writers and Erasers.

Wiedmer L, Eberle SA, Bedi RK, Śledź P, Caflisch A. Wiedmer L, et al. Among authors: caflisch a. Anal Chem. 2019 Feb 19;91(4):3078-3084. doi: 10.1021/acs.analchem.8b05500. Epub 2019 Feb 4. Anal Chem. 2019. PMID: 30715855

8

Selectively Disrupting m⁶A-Dependent Protein-RNA Interactions with Fragments.

Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, Sharpe ME, Caflisch A, Sledz P. Bedi RK, et al. Among authors: caflisch a. ACS Chem Biol. 2020 Mar 20;15(3):618-625. doi: 10.1021/acschembio.9b00894. Epub 2020 Mar 2. ACS Chem Biol. 2020. PMID: 32101404

9

Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m⁶A) Recognition by the Reader Domain of YTHDC1.

Li Y, Bedi RK, Wiedmer L, Sun X, Huang D, Caflisch A. Li Y, et al. Among authors: caflisch a. J Chem Theory Comput. 2021 Feb 9;17(2):1240-1249. doi: 10.1021/acs.jctc.0c01136. Epub 2021 Jan 20. J Chem Theory Comput. 2021. PMID: 33472367 Free article.

10

Fragment Ligands of the m⁶A-RNA Reader YTHDF2.

Nai F, Nachawati R, Zálešák F, Wang X, Li Y, Caflisch A. Nai F, et al. Among authors: caflisch a. ACS Med Chem Lett. 2022 Aug 17;13(9):1500-1509. doi: 10.1021/acsmedchemlett.2c00303. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36110386 Free PMC article.

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