Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity

Nat Prod Commun. 2010 Aug;5(8):1201-4.

Abstract

From the bulbs of Zephyranthes robusta Baker (Amaryllidaceae), seven known compounds, belonging to four structural types of Amaryllidaceae alkaloids, were identified and quantified by GC-MS. The alkaloid extract from the bulbs showed promising acetylcholinesterase and butyrylcholinesterase inhibitory activities against HuAChE (IC50 = 35.9 +/- 3.5 microg/mL) and HuBuChE (IC50 = 190.9 +/- 8.2 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amaryllidaceae Alkaloids / analysis*
  • Amaryllidaceae Alkaloids / pharmacology
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / pharmacology*
  • Gas Chromatography-Mass Spectrometry / methods*
  • Humans
  • Liliaceae / chemistry*

Substances

  • Amaryllidaceae Alkaloids
  • Cholinesterase Inhibitors
  • Butyrylcholinesterase