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3,041 results
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Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Breslin HJ, Diamond CJ, Kavash RW, Cai C, Dyatkin AB, Miskowski TA, Zhang SP, Wade PR, Hornby PJ, He W. Breslin HJ, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4869-72. doi: 10.1016/j.bmcl.2012.05.042. Epub 2012 May 24. Bioorg Med Chem Lett. 2012. PMID: 22695132
Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
Zhang X, Hufnagel H, Markotan T, Lanter J, Cai C, Hou C, Singer M, Opas E, McKenney S, Crysler C, Johnson D, Sui Z. Zhang X, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5577-82. doi: 10.1016/j.bmcl.2011.06.080. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21783361
Identification of potent phenyl imidazoles as opioid receptor agonists.
Breslin HJ, Cai C, Miskowski TA, Coutinho SV, Zhang SP, Hornby P, He W. Breslin HJ, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2505-8. doi: 10.1016/j.bmcl.2006.01.082. Epub 2006 Feb 17. Bioorg Med Chem Lett. 2006. PMID: 16483774
Using previously reported opioid receptor (OR) agonist analogs 4a-c as starting points, the structure-activity relationship (SAR) for their related series has been further refined. ...
Using previously reported opioid receptor (OR) agonist analogs 4a-c as starting points, the structure-activity relationship (SAR) for …
Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Codd EE, Ma J, Zhang SP, Stone DJ Jr, Colburn RW, Brandt MR, Chevalier KM, Zhu Y, Peng S, Cai C, Acton PD, Flores CM. Codd EE, et al. Pharmacol Biochem Behav. 2010 Aug;96(2):130-5. doi: 10.1016/j.pbb.2010.04.020. Epub 2010 May 12. Pharmacol Biochem Behav. 2010. PMID: 20438745
Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists.
Zhang X, Cai C, Winters M, Wells M, Wall M, Lanter J, Sui Z, Ma J, Novack A, Nashashibi I, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3272-3278. doi: 10.1016/j.bmcl.2017.06.028. Epub 2017 Jun 12. Bioorg Med Chem Lett. 2017. PMID: 28642104
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.
Cai C, McComsey DF, Hou C, O'Neill JC, Opas E, McKenney S, Johnson D, Sui Z. Cai C, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1239-42. doi: 10.1016/j.bmcl.2013.05.024. Epub 2013 Jun 28. Bioorg Med Chem Lett. 2014. PMID: 23916257
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists.
Cai C, Kang FA, Hou C, O'Neill JC, Opas E, McKenney S, Johnson D, Sui Z. Cai C, et al. Bioorg Med Chem Lett. 2013 Jan 1;23(1):351-4. doi: 10.1016/j.bmcl.2012.10.069. Epub 2012 Oct 24. Bioorg Med Chem Lett. 2013. PMID: 23182090
Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes.
Zhang X, Cai C, Sui Z, Macielag M, Wang Y, Yan W, Suckow A, Hua H, Bell A, Haug P, Clapper W, Jenkinson C, Gunnet J, Leonard J, Murray WV. Zhang X, et al. ACS Med Chem Lett. 2017 Jul 27;8(9):947-952. doi: 10.1021/acsmedchemlett.7b00233. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947942 Free PMC article.
Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling.
Kang FA, Lanter JC, Cai C, Sui Z, Murray WV. Kang FA, et al. Chem Commun (Camb). 2010 Feb 28;46(8):1347-9. doi: 10.1039/b917777a. Epub 2010 Jan 11. Chem Commun (Camb). 2010. PMID: 20449299
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C-OH bond activations with direct C(sp(2))-C(sp) bond formation, which is in line with ideal synthesis using readily availa …
The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C-H/C
Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.
Codd EE, Baker J, Brandt MR, Bryant S, Cai C, Carson JR, Chevalier KM, Colburn RW, Coogan TP, Dax SL, Decorte B, Kemmerer M, Legrand EK, Lenhard JM, Leone AM, Lin L, Mabus JR, McDonnell ME, McMillian MK, McNally JJ, Stone DJ Jr, Wang CY, Zhang SP, Flores CM. Codd EE, et al. Toxicol Sci. 2010 Oct;117(2):493-504. doi: 10.1093/toxsci/kfq200. Epub 2010 Jul 8. Toxicol Sci. 2010. PMID: 20616206
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