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Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: cai x. Cell. 2026 Apr 27:S0092-8674(26)00345-4. doi: 10.1016/j.cell.2026.03.044. Online ahead of print. Cell. 2026. PMID: 42049019 Free article.
A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster D, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Usaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Rojas Echenique JI, Gacesa R, Granda Farias A, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim J, Lin K, Lu X, Nami B, Nixon A, Mikolajewicz N, Nedyalkova L, Rohde T, Sartori Rodrigues M, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Thomson Taylor D, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C. Billmann M, et al. Among authors: cai x. bioRxiv [Preprint]. 2025 Jul 2:2025.06.30.662193. doi: 10.1101/2025.06.30.662193. bioRxiv. 2025. PMID: 40631273 Free PMC article. Preprint.
Abnormal global alternative RNA splicing in COVID-19 patients.
Wang C, Chen L, Chen Y, Jia W, Cai X, Liu Y, Ji F, Xiong P, Liang A, Liu R, Guan Y, Cheng Z, Weng Y, Wang W, Duan Y, Kuang D, Xu S, Cai H, Xia Q, Yang D, Wang MW, Yang X, Zhang J, Cheng C, Liu L, Liu Z, Liang R, Wang G, Li Z, Xia H, Xia T. Wang C, et al. Among authors: cai x, cai h. PLoS Genet. 2022 Apr 14;18(4):e1010137. doi: 10.1371/journal.pgen.1010137. eCollection 2022 Apr. PLoS Genet. 2022. PMID: 35421082 Free PMC article.
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases.
Wu M, Chen Y, Xia H, Wang C, Tan CY, Cai X, Liu Y, Ji F, Xiong P, Liu R, Guan Y, Duan Y, Kuang D, Xu S, Cai H, Xia Q, Yang D, Wang MW, Chiu IM, Cheng C, Ahern PP, Liu L, Wang G, Surana NK, Xia T, Kasper DL. Wu M, et al. Among authors: cai x, cai h. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28336-28343. doi: 10.1073/pnas.2018030117. Epub 2020 Oct 20. Proc Natl Acad Sci U S A. 2020. PMID: 33082228 Free PMC article.
Whole-genome doubling drives immune evasion by silencing antigen presentation.
Foidart P, Li Z, Cai X, Seehawer M, Brown DD, Tawawalla A, Baldominos P, Parvin S, Nishida J, Rojas-Jimenez E, Bui TM, Diciaccio B, Kumar R, Schlegel BT, Goyette MA, Scales T, Yan P, Qiu X, Li R, Jiang Y, Xie Y, Aarabi M, Huang XY, Stevens LE, Cejas P, Mangiante L, Sotomayor Vivas CI, Houlahan KE, Curtis C, Oesterreich S, Harris IS, Letai AG, Lee AV, Long HW, Agudo J, Polyak K. Foidart P, et al. Among authors: cai x. Cancer Cell. 2026 May 7:S1535-6108(26)00218-7. doi: 10.1016/j.ccell.2026.04.007. Online ahead of print. Cancer Cell. 2026. PMID: 42102810
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