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Somatic inactivation of Pkd2 results in polycystic kidney disease.
Wu G, D'Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S. Wu G, et al. Among authors: cai y. Cell. 1998 Apr 17;93(2):177-88. doi: 10.1016/s0092-8674(00)81570-6. Cell. 1998. PMID: 9568711
Altered trafficking and stability of polycystins underlie polycystic kidney disease.
Cai Y, Fedeles SV, Dong K, Anyatonwu G, Onoe T, Mitobe M, Gao JD, Okuhara D, Tian X, Gallagher AR, Tang Z, Xie X, Lalioti MD, Lee AH, Ehrlich BE, Somlo S. Cai Y, et al. J Clin Invest. 2014 Dec;124(12):5129-44. doi: 10.1172/JCI67273. Epub 2014 Nov 3. J Clin Invest. 2014. PMID: 25365220 Free PMC article.
Polycystin-2 is an intracellular calcium release channel.
Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S. Koulen P, et al. Among authors: cai y. Nat Cell Biol. 2002 Mar;4(3):191-7. doi: 10.1038/ncb754. Nat Cell Biol. 2002. PMID: 11854751
Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S. Davila S, et al. Among authors: cai y. Nat Genet. 2004 Jun;36(6):575-7. doi: 10.1038/ng1357. Epub 2004 May 9. Nat Genet. 2004. PMID: 15133510
Vascular expression of polycystin-2.
Torres VE, Cai Y, Chen XI, Wu GQ, Geng L, Cleghorn KA, Johnson CM, Somlo S. Torres VE, et al. Among authors: cai y. J Am Soc Nephrol. 2001 Jan;12(1):1-9. doi: 10.1681/ASN.V1211. J Am Soc Nephrol. 2001. PMID: 11134244
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