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Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.
Smit E, Caiment F, Piepers J, Kleinjans JCS, van den Beucken T. Smit E, et al. Among authors: caiment f. Toxicol Lett. 2018 Oct 1;295:144-152. doi: 10.1016/j.toxlet.2018.06.009. Epub 2018 Jun 12. Toxicol Lett. 2018. PMID: 29906497
Transcriptomic study of the toxic mechanism triggered by beauvericin in Jurkat cells.
Escrivá L, Jennen D, Caiment F, Manyes L. Escrivá L, et al. Among authors: caiment f. Toxicol Lett. 2018 Mar 1;284:213-221. doi: 10.1016/j.toxlet.2017.11.035. Epub 2017 Dec 1. Toxicol Lett. 2018. PMID: 29203277
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J. Kuepfer L, et al. Among authors: caiment f. Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. Arch Toxicol. 2018. PMID: 28852801 Free PMC article. No abstract available.
Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes.
Wolters JEJ, van Breda SGJ, Caiment F, Claessen SM, de Kok TMCM, Kleinjans JCS. Wolters JEJ, et al. Among authors: caiment f. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13. Chem Res Toxicol. 2017. PMID: 28853863 Free PMC article.
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.
Verheijen M, Schrooders Y, Gmuender H, Nudischer R, Clayton O, Hynes J, Niederer S, Cordes H, Kuepfer L, Kleinjans J, Caiment F. Verheijen M, et al. Among authors: caiment f. Toxicol Lett. 2018 Sep 15;294:184-192. doi: 10.1016/j.toxlet.2018.05.029. Epub 2018 May 24. Toxicol Lett. 2018. PMID: 29803840
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.
Wolters JEJ, van Breda SGJ, Grossmann J, Fortes C, Caiment F, Kleinjans JCS. Wolters JEJ, et al. Among authors: caiment f. Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6. Toxicol Lett. 2018. PMID: 29501571
Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.
Krauskopf J, de Kok TM, Schomaker SJ, Gosink M, Burt DA, Chandler P, Warner RL, Johnson KJ, Caiment F, Kleinjans JC, Aubrecht J. Krauskopf J, et al. Among authors: caiment f. PLoS One. 2017 May 17;12(5):e0177928. doi: 10.1371/journal.pone.0177928. eCollection 2017. PLoS One. 2017. PMID: 28545106 Free PMC article.
Development and regulatory application of microRNA biomarkers.
Krauskopf J, Verheijen M, Kleinjans JC, de Kok TM, Caiment F. Krauskopf J, et al. Among authors: caiment f. Biomark Med. 2015;9(11):1137-51. doi: 10.2217/bmm.15.50. Epub 2015 Oct 26. Biomark Med. 2015. PMID: 26502281 Review.
Assessing compound carcinogenicity in vitro using connectivity mapping.
Caiment F, Tsamou M, Jennen D, Kleinjans J. Caiment F, et al. Carcinogenesis. 2014 Jan;35(1):201-7. doi: 10.1093/carcin/bgt278. Epub 2013 Aug 12. Carcinogenesis. 2014. PMID: 23940306
Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.
Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC. Krauskopf J, et al. Among authors: caiment f. Toxicol Sci. 2015 Feb;143(2):268-76. doi: 10.1093/toxsci/kfu232. Epub 2014 Oct 29. Toxicol Sci. 2015. PMID: 25359176
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