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Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.
Cairns P, Proctor AJ, Knowles MA. Cairns P, et al. Oncogene. 1991 Dec;6(12):2305-9. Oncogene. 1991. PMID: 1766677
When RB loss was compared with tumour grade and stage, an association between high tumour grade and RB loss (0.005 greater than P greater than 0.001) and between muscle invasion and RB loss (P greater than 0.001) was found. ...
When RB loss was compared with tumour grade and stage, an association between high tumour grade and RB loss (0.005 greater than P gre …
Absence of TSG101 transcript abnormalities in human cancers.
Trink B, Pai SI, Spunt SL, Raman V, Cairns P, Jen J, Gabrielson E, Sukumar S, Sidransky D. Trink B, et al. Oncogene. 1998 May 28;16(21):2815-8. doi: 10.1038/sj.onc.1201795. Oncogene. 1998. PMID: 9652749
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Cairns P, Evron E, Okami K, Halachmi N, Esteller M, Herman JG, Bose S, Wang SI, Parsons R, Sidransky D. Cairns P, et al. Oncogene. 1998 Jun 18;16(24):3215-8. doi: 10.1038/sj.onc.1201855. Oncogene. 1998. PMID: 9671402
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma.
Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek MM, Crossey PA, Richards FM, Cairns P, Affara NA, Ferguson-Smith MA, et al. Foster K, et al. Hum Mol Genet. 1994 Dec;3(12):2169-73. doi: 10.1093/hmg/3.12.2169. Hum Mol Genet. 1994. PMID: 7881415

Detailed histopathology was available for 59 of the tumours investigated: 18 of 43 (42%) RCC with a clear cell appearance had a somatic VHL gene mutation but none of 16 non-clear cell RCC (eight chromophilic, three chromophobe and five oncocytoma) (chi2 = 7.77, P < 0.02

Detailed histopathology was available for 59 of the tumours investigated: 18 of 43 (42%) RCC with a clear cell appearance had a somatic VHL …
Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma.
Polascik TJ, Cairns P, Chang WY, Schoenberg MP, Sidransky D. Polascik TJ, et al. Cancer Res. 1995 Nov 15;55(22):5396-9. Cancer Res. 1995. PMID: 7585608
Fine mapping was accomplished using up to 15 polymorphic markers on the p arm and 19 markers on the q arm. We identified a 3-cM minimal area of loss on the p arm between microsatellite markers D4S1608 and D4S404 deleted in 82 tumors (29%). ...
Fine mapping was accomplished using up to 15 polymorphic markers on the p arm and 19 markers on the q arm. We identified a 3-cM minim …
Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney.
Schoenberg M, Cairns P, Brooks JD, Marshall FF, Epstein JI, Isaacs WB, Sidransky D. Schoenberg M, et al. Genes Chromosomes Cancer. 1995 Jan;12(1):76-80. doi: 10.1002/gcc.2870120115. Genes Chromosomes Cancer. 1995. PMID: 7534117
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression.
Xu HJ, Cairns P, Hu SX, Knowles MA, Benedict WF. Xu HJ, et al. Int J Cancer. 1993 Mar 12;53(5):781-4. doi: 10.1002/ijc.2910530513. Int J Cancer. 1993. PMID: 8449603

Absence of RB-protein expression was found in 15 of 17 tumors in which LOH at the RB locus was identified, whereas 31 of 36 tumors from informative patients which showed no LOH had a normal RB-protein pattern (p < 0.001). Altered RB-protein expression was also more freq

Absence of RB-protein expression was found in 15 of 17 tumors in which LOH at the RB locus was identified, whereas 31 of 36 tumors from info …
Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22.
Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA, Maher ER. Foster K, et al. Br J Cancer. 1994 Feb;69(2):230-4. doi: 10.1038/bjc.1994.44. Br J Cancer. 1994. PMID: 8297719 Free PMC article.
We also confirmed previous suggestions that chromosome 3p allele loss is not a feature of papillary RCC (P < 0.05)....
We also confirmed previous suggestions that chromosome 3p allele loss is not a feature of papillary RCC (P < 0.05)....
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