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Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP, Reddy H, Caivano M, Cohen P. Davies SP, et al. Among authors: caivano m. Biochem J. 2000 Oct 1;351(Pt 1):95-105. doi: 10.1042/0264-6021:3510095. Biochem J. 2000. PMID: 10998351 Free PMC article.
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages.
Caivano M. Caivano M. FEBS Lett. 1998 Jun 16;429(3):249-53. doi: 10.1016/s0014-5793(98)00578-x. FEBS Lett. 1998. PMID: 9662426
Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages.
Caivano M, Cohen P. Caivano M, et al. J Immunol. 2000 Mar 15;164(6):3018-25. doi: 10.4049/jimmunol.164.6.3018. J Immunol. 2000. PMID: 10706690
The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors.
Caivano M, Gorgoni B, Cohen P, Poli V. Caivano M, et al. J Biol Chem. 2001 Dec 28;276(52):48693-701. doi: 10.1074/jbc.M108282200. Epub 2001 Oct 19. J Biol Chem. 2001. PMID: 11668179
The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts.
Gorgoni B, Caivano M, Arizmendi C, Poli V. Gorgoni B, et al. Among authors: caivano m. J Biol Chem. 2001 Nov 2;276(44):40769-77. doi: 10.1074/jbc.M106865200. Epub 2001 Aug 24. J Biol Chem. 2001. PMID: 11522796
15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide.
Caivano M, Rodriguez C, Cohen P, Alemany S. Caivano M, et al. J Biol Chem. 2003 Dec 26;278(52):52124-30. doi: 10.1074/jbc.M306583200. Epub 2003 Oct 13. J Biol Chem. 2003. PMID: 14557273
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.
Biggadike K, Caivano M, Clackers M, Coe DM, Hardy GW, Humphreys D, Jones HT, House D, Miles-Williams A, Skone PA, Uings I, Weller V, McLay IM, Macdonald SJ. Biggadike K, et al. Among authors: caivano m. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4846-50. doi: 10.1016/j.bmcl.2009.06.020. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19592247
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Ward RV, Davis JB, Gray CW, Barton AJ, Bresciani LG, Caivano M, Murphy VF, Duff K, Hutton M, Hardy J, Roberts GW, Karran EH. Ward RV, et al. Among authors: caivano m. Neurodegeneration. 1996 Dec;5(4):293-8. doi: 10.1006/neur.1996.0040. Neurodegeneration. 1996. PMID: 9117540
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
Rimland J, Dunne A, Hunjan SS, Sasse R, Uings I, Montanari D, Caivano M, Shah P, Standing D, Gray D, Brown D, Cairns W, Trump R, Smith PW, Bertheleme N, D'Alessandro P, Gul S, Vimal M, Smith DN, Watson SP. Rimland J, et al. Among authors: caivano m. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. doi: 10.1016/j.bmcl.2010.01.133. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20202837
Design and synthesis of an array of selective androgen receptor modulators.
Trump RP, Blanc JB, Stewart EL, Brown PJ, Caivano M, Gray DW, Hoekstra WJ, Willson TM, Han B, Turnbull P. Trump RP, et al. Among authors: caivano m. J Comb Chem. 2007 Jan-Feb;9(1):107-14. doi: 10.1021/cc060096e. J Comb Chem. 2007. PMID: 17206838
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