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Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?
Caldwell GW, Masucci JA, Yan Z, Hageman W. Caldwell GW, et al. Eur J Drug Metab Pharmacokinet. 2004 Apr-Jun;29(2):133-43. doi: 10.1007/BF03190588. Eur J Drug Metab Pharmacokinet. 2004. PMID: 15230342
Excretion and metabolism of the antihypertensive agent, RWJ-26240 (McN-5691) in dogs.
Wu WN, Masucci JA, Caldwell GW, Carson JR. Wu WN, et al. Among authors: caldwell gw. Drug Metab Dispos. 1998 Feb;26(2):115-25. Drug Metab Dispos. 1998. PMID: 9456297
Using capillary electrophoresis/frontal analysis to screen drugs interacting with human serum proteins.
McDonnell PA, Caldwell GW, Masucci JA. McDonnell PA, et al. Among authors: caldwell gw. Electrophoresis. 1998 Mar;19(3):448-54. doi: 10.1002/elps.1150190315. Electrophoresis. 1998. PMID: 9551800
Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions.
Caldwell GW, Masucci JA, Evangelisto M, White R. Caldwell GW, et al. J Chromatogr A. 1998 Mar 27;800(2):161-9. doi: 10.1016/s0021-9673(97)01143-6. J Chromatogr A. 1998. PMID: 9561760
High throughput liquid chromatography-mass spectrometry assessment of the metabolic activity of commercially available hepatocytes from 96-well plates.
Caldwell GW, Masucci JA, Chacon E. Caldwell GW, et al. Comb Chem High Throughput Screen. 1999 Feb;2(1):39-51. Comb Chem High Throughput Screen. 1999. PMID: 10420975
Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR Wistar rats and Beagle dogs.
Wu WN, Caldwell GW, Masucci JA. Wu WN, et al. Among authors: caldwell gw. Eur J Drug Metab Pharmacokinet. 2001 Jul-Sep;26(3):155-66. doi: 10.1007/BF03190391. Eur J Drug Metab Pharmacokinet. 2001. PMID: 11695715
Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs.
Wu WN, Caldwell GW, Masucci JA, Gauthier AD. Wu WN, et al. Among authors: caldwell gw. Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):263-71. doi: 10.1007/BF03226381. Eur J Drug Metab Pharmacokinet. 2001. PMID: 11808869
The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery.
Caldwell GW, Ritchie DM, Masucci JA, Hageman W, Yan Z. Caldwell GW, et al. Curr Top Med Chem. 2001 Nov;1(5):353-66. doi: 10.2174/1568026013394949. Curr Top Med Chem. 2001. PMID: 11899102 Review.
Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery.
Yan Z, Caldwell GW. Yan Z, et al. Among authors: caldwell gw. Curr Top Med Chem. 2001 Nov;1(5):403-25. doi: 10.2174/1568026013395001. Curr Top Med Chem. 2001. PMID: 11899105 Review.
Evaluation of the excretion and metabolism of the new analgesic agent RWJ-22757 in male and female CR Wistar rats.
Wu WN, Caldwell GW, Masucci JA. Wu WN, et al. Among authors: caldwell gw. J Pharm Biomed Anal. 2002 May 15;28(3-4):659-71. doi: 10.1016/s0731-7085(01)00704-x. J Pharm Biomed Anal. 2002. PMID: 12008146
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