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Calibrating longitudinal cognition in Alzheimer's disease across diverse test batteries and datasets.
Gross AL, Sherva R, Mukherjee S, Newhouse S, Kauwe JS, Munsie LM, Waterston LB, Bennett DA, Jones RN, Green RC, Crane PK; Alzheimer's Disease Neuroimaging Initiative; GENAROAD Consortium; AD Genetics Consortium. Gross AL, et al. Neuroepidemiology. 2014;43(3-4):194-205. doi: 10.1159/000367970. Epub 2014 Nov 13. Neuroepidemiology. 2014. PMID: 25402421 Free PMC article.
BACKGROUND: We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies with different neuropsychological batteries. METHODS: We examined four approaches to calibrate cognitive performance in nine …
BACKGROUND: We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies w …
The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods.
Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW. Jack CR Jr, et al. J Magn Reson Imaging. 2008 Apr;27(4):685-91. doi: 10.1002/jmri.21049. J Magn Reson Imaging. 2008. PMID: 18302232 Free PMC article.
The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's disease. ...The protocol selected for the ADNI study …
The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of health …
A panel of blood lipids associated with cognitive performance, brain atrophy, and Alzheimer's diagnosis: A longitudinal study of elders without dementia.
Ma YH, Shen XN, Xu W, Huang YY, Li HQ, Tan L, Tan CC, Dong Q, Tan L, Yu JT; Alzheimer's Disease Neuroimaging Initiative. Ma YH, et al. Alzheimers Dement (Amst). 2020 Sep 15;12(1):e12041. doi: 10.1002/dad2.12041. eCollection 2020. Alzheimers Dement (Amst). 2020. PMID: 32995461 Free PMC article.
INTRODUCTION: We sought lipid-metabolic biomarkers involved in the processes underlying cognitive decline and detected them in association with Alzheimer's disease (AD) phenotypes. ...RESULTS: A model incorporating 17 selected lipids showed good discri …
INTRODUCTION: We sought lipid-metabolic biomarkers involved in the processes underlying cognitive decline and detected them in associ …
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.
Cristofano A, Sapere N, La Marca G, Angiolillo A, Vitale M, Corbi G, Scapagnini G, Intrieri M, Russo C, Corso G, Di Costanzo A. Cristofano A, et al. PLoS One. 2016 May 19;11(5):e0155694. doi: 10.1371/journal.pone.0155694. eCollection 2016. PLoS One. 2016. PMID: 27196316 Free PMC article.
This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in patients with or at risk of Alzheimer's disease. Twenty-nine patients with probable Alzheimer's disease
This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in pa …
No difference in dementia prediction between apolipoprotein E4 and the ischemic score.
Oveisgharan S, Hachinski V. Oveisgharan S, et al. Alzheimers Dement. 2020 Nov;16(11):1596-1599. doi: 10.1002/alz.12139. Epub 2020 Jul 30. Alzheimers Dement. 2020. PMID: 32729966
INTRODUCTION: Few biomarkers exist for early detection of vascular cognitive impairment. We examined whether the Hachinski Ischemic Scale (HIS) can predict dementia in elderly. ...Dementia discrimination of the HIS model was not different from the APOE e4 model (area under …
INTRODUCTION: Few biomarkers exist for early detection of vascular cognitive impairment. We examined whether the Hachinski Ischemic S …
Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies.
Licher S, Leening MJG, Yilmaz P, Wolters FJ, Heeringa J, Bindels PJE; Alzheimer’s Disease Neuroimaging Initiative, Vernooij MW, Stephan BCM, Steyerberg EW, Ikram MK, Ikram MA. Licher S, et al. Am J Psychiatry. 2019 Jul 1;176(7):543-551. doi: 10.1176/appi.ajp.2018.18050566. Epub 2018 Dec 11. Am J Psychiatry. 2019. PMID: 30525906
Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated in the Dutch population-based Epidemiological Prevention Study of Zoetermeer and in the Alzheimer's Disease Neuroimagin …
Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated …
A new algorithm for predicting time to disease endpoints in Alzheimer's disease patients.
Razlighi QR, Stallard E, Brandt J, Blacker D, Albert M, Scarmeas N, Kinosian B, Yashin AI, Stern Y. Razlighi QR, et al. J Alzheimers Dis. 2014;38(3):661-8. doi: 10.3233/JAD-131142. J Alzheimers Dis. 2014. PMID: 24064468 Free PMC article.
OBJECTIVE: To develop and validate a prediction algorithm that uses data from a single visit to estimate time to important disease endpoints for individual Alzheimer's disease patients. METHOD: Two separate study cohorts (Predictors 1, N = 252; Predict …
OBJECTIVE: To develop and validate a prediction algorithm that uses data from a single visit to estimate time to important disease en …
Studying the Progression of Amyloid Pathology and Its Therapy Using Translational Longitudinal Model of Accumulation and Distribution of Amyloid Beta.
Karelina T, Demin O Jr, Demin O, Duvvuri S, Nicholas T. Karelina T, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Oct;6(10):676-685. doi: 10.1002/psp4.12249. Epub 2017 Sep 28. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28913897 Free PMC article.
Long-term effects of amyloid targeted therapy can be studied using a mechanistic translational model of amyloid beta (Abeta) distribution and aggregation calibrated on published data in mouse and human species. Alzheimer disease (AD) pathology is modeled util …
Long-term effects of amyloid targeted therapy can be studied using a mechanistic translational model of amyloid beta (Abeta) distribution an …
Network Diffusion Modeling Explains Longitudinal Tau PET Data.
Schäfer A, Mormino EC, Kuhl E. Schäfer A, et al. Front Neurosci. 2020 Dec 23;14:566876. doi: 10.3389/fnins.2020.566876. eCollection 2020. Front Neurosci. 2020. PMID: 33424532 Free PMC article.
Alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau protein. ...Here we combine longitudinal positron emission tomography and dynamic network modeling to test the hypothesis that misfol
Alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau
Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils.
Boyes RG, Gunter JL, Frost C, Janke AL, Yeatman T, Hill DL, Bernstein MA, Thompson PM, Weiner MW, Schuff N, Alexander GE, Killiany RJ, DeCarli C, Jack CR, Fox NC; ADNI Study. Boyes RG, et al. Neuroimage. 2008 Feb 15;39(4):1752-62. doi: 10.1016/j.neuroimage.2007.10.026. Epub 2007 Oct 30. Neuroimage. 2008. PMID: 18063391 Free PMC article.
Measures of structural brain change based on longitudinal MR imaging are increasingly important but can be degraded by intensity non-uniformity. ...We assessed the ability of the non-parametric non-uniform intensity normalization (N3) technique to correct non-uniformity in …
Measures of structural brain change based on longitudinal MR imaging are increasingly important but can be degraded by intensity non- …
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