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Calibrating longitudinal cognition in Alzheimer's disease across diverse test batteries and datasets.
Gross AL, Sherva R, Mukherjee S, Newhouse S, Kauwe JS, Munsie LM, Waterston LB, Bennett DA, Jones RN, Green RC, Crane PK; Alzheimer's Disease Neuroimaging Initiative; GENAROAD Consortium; AD Genetics Consortium. Gross AL, et al. Neuroepidemiology. 2014;43(3-4):194-205. doi: 10.1159/000367970. Epub 2014 Nov 13. Neuroepidemiology. 2014. PMID: 25402421 Free PMC article.
BACKGROUND: We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies with different neuropsychological batteries. METHODS: We examined four approaches to calibrate cognitive performance in nine …
BACKGROUND: We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies w …
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
Kang M, Ang TFA, Devine SA, Sherva R, Mukherjee S, Trittschuh EH, Gibbons LE, Scollard P, Lee M, Choi SE, Klinedinst B, Nakano C, Dumitrescu LC, Durant A, Hohman TJ, Cuccaro ML, Saykin AJ, Kukull WA, Bennett DA, Wang LS, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Crane PK, Au R, Lunetta KL, Mez JB, Farrer LA. Kang M, et al. Mol Neurodegener. 2023 Jun 22;18(1):40. doi: 10.1186/s13024-023-00633-4. Mol Neurodegener. 2023. PMID: 37349795 Free PMC article.
BACKGROUND: More than 75 common variant loci account for only a portion of the heritability for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can be deduced by exploring associations with AD-related endophenotypes. METHODS …
BACKGROUND: More than 75 common variant loci account for only a portion of the heritability for Alzheimer's disease (AD …
Establishment of a mild cognitive impairment risk model in middle-aged and older adults: a longitudinal study.
Zhang X, Fan H, Guo C, Li Y, Han X, Xu Y, Wang H, Zhang T. Zhang X, et al. Neurol Sci. 2024 Apr 20. doi: 10.1007/s10072-024-07536-2. Online ahead of print. Neurol Sci. 2024. PMID: 38642322
BACKGROUND: Early identification individuals at high risk of mild cognitive impairment (MCI) is essential for prevention and intervention strategies of dementia, such as Alzheimer's disease. ...METHODS: In a longitudinal population-based cohort …
BACKGROUND: Early identification individuals at high risk of mild cognitive impairment (MCI) is essential for prevention and interven …
Testing a Polygenic Risk Score for Morphological Microglial Activation in Alzheimer's Disease and Aging.
Tio ES, Hohman TJ, Milic M, Bennett DA, Felsky D; Alzheimer’s Disease Neuroimaging Initiative. Tio ES, et al. J Alzheimers Dis. 2023;94(4):1549-1561. doi: 10.3233/JAD-230434. J Alzheimers Dis. 2023. PMID: 37458040 Free PMC article.
BACKGROUND: Neuroinflammation and the activation of microglial cells are among the earliest events in Alzheimer's disease (AD). However, direct observation of microglia in living people is not currently possible. ...OBJECTIVE: We sought to determine whether a …
BACKGROUND: Neuroinflammation and the activation of microglial cells are among the earliest events in Alzheimer's disease
Linking self-perceived cognitive functioning questionnaires using item response theory: The subjective cognitive decline initiative.
Rabin LA, Sikkes SAM, Tommet D, Jones RN, Crane PK, Elbulok-Charcape MM, Dubbelman MA, Koscik R, Amariglio RE, Buckley RF, Boada M, Chételat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Johnson S, Katz MJ, Lipton RB, Luck T, Margioti E, Maruff P, Molinuevo JL, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez-Gomez O, Sachdev PS, Saykin AJ, Scarmeas N, Smart C, Snitz BE, Sperling RA, Taler V, van der Flier WM, van Harten AC, Wagner M, Wolfsgruber S; Alzheimer’s Disease Neuroimaging Initiative; Canadian Longitudinal Study on Aging; Health and Aging Brain Study: Health Disparities (HABS-HD) Study Team. Rabin LA, et al. Neuropsychology. 2023 May;37(4):463-499. doi: 10.1037/neu0000888. Neuropsychology. 2023. PMID: 37276136 Free PMC article.
OBJECTIVE: Self-perceived cognitive functioning, considered highly relevant in the context of aging and dementia, is assessed in numerous ways-hindering the comparison of findings across studies and settings. ...These top items originated from distinct questionnaires and v …
OBJECTIVE: Self-perceived cognitive functioning, considered highly relevant in the context of aging and dementia, is assessed in nume …
Network Diffusion Modeling Explains Longitudinal Tau PET Data.
Schäfer A, Mormino EC, Kuhl E. Schäfer A, et al. Front Neurosci. 2020 Dec 23;14:566876. doi: 10.3389/fnins.2020.566876. eCollection 2020. Front Neurosci. 2020. PMID: 33424532 Free PMC article.
Alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau protein. ...Here we combine longitudinal positron emission tomography and dynamic network modeling to test the hypothesis that misfol
Alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau
Validity of three risk prediction models for dementia or cognitive impairment in Australia.
Geethadevi GM, Peel R, Bell JS, Cross AJ, Hancock S, Ilomaki J, Tang T, Attia J, George J. Geethadevi GM, et al. Age Ageing. 2022 Dec 5;51(12):afac307. doi: 10.1093/ageing/afac307. Age Ageing. 2022. PMID: 36585910 Free PMC article.
OBJECTIVES: (i) to investigate the predictive validity of the Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI), LIfestyle for BRAin Health (LIBRA) Index and cardiovascular risk factors, ageing and dementia study (CAIDE) models for pred …
OBJECTIVES: (i) to investigate the predictive validity of the Australian National University-Alzheimer's Disease Risk I …
Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia.
Cristofano A, Sapere N, La Marca G, Angiolillo A, Vitale M, Corbi G, Scapagnini G, Intrieri M, Russo C, Corso G, Di Costanzo A. Cristofano A, et al. PLoS One. 2016 May 19;11(5):e0155694. doi: 10.1371/journal.pone.0155694. eCollection 2016. PLoS One. 2016. PMID: 27196316 Free PMC article.
This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in patients with or at risk of Alzheimer's disease. Twenty-nine patients with probable Alzheimer's disease
This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in pa …
Factor analyses of the ADNI neuropsychological battery: An examination of diagnostic and longitudinal invariance.
Chang M, Brainerd CJ. Chang M, et al. Neuropsychology. 2021 May;35(4):434-450. doi: 10.1037/neu0000736. Neuropsychology. 2021. PMID: 34043393
OBJECTIVE: In the Alzheimer's Disease Neuroimaging Initiative (ADNI), cognitive function was tracked across multiple years by a comprehensive neuropsychological battery. ...METHOD: We used exploratory and confirmatory factor analyses to investigate the …
OBJECTIVE: In the Alzheimer's Disease Neuroimaging Initiative (ADNI), cognitive function was tracked across mult …
Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies.
Licher S, Leening MJG, Yilmaz P, Wolters FJ, Heeringa J, Bindels PJE; Alzheimer’s Disease Neuroimaging Initiative; Vernooij MW, Stephan BCM, Steyerberg EW, Ikram MK, Ikram MA. Licher S, et al. Am J Psychiatry. 2019 Jul 1;176(7):543-551. doi: 10.1176/appi.ajp.2018.18050566. Epub 2018 Dec 11. Am J Psychiatry. 2019. PMID: 30525906
Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated in the Dutch population-based Epidemiological Prevention Study of Zoetermeer and in the Alzheimer's Disease Neuroimagin …
Model performance was assessed using optimism-corrected C-statistics and calibration plots, and the models were externally validated …
19 results