Effects of 5-hydroxytryptophan, oxotermorine, and tetrahydroaminoacridine on apomorphine-induced stereotypy

Psychopharmacology (Berl). 1978 Jun 15;58(1):115-6. doi: 10.1007/BF00426800.

Abstract

The stereotyped behavior induced by apomorphine in rats was inhibited by oxotremorine and tetrahydroaminoacridine (THA). 5-Hydroxytryptophan (5-HTP) did not change stereotypy scores. These data show influence of cholinergic mechanisms on such behavior. Possible clinical applications are discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 5-Hydroxytryptophan / pharmacology*
  • Acridines / pharmacology*
  • Animals
  • Apomorphine / pharmacology*
  • Behavior / drug effects*
  • Humans
  • Male
  • Oxotremorine / pharmacology*
  • Rats
  • Stereotyped Behavior / drug effects*
  • Tacrine / pharmacology*
  • Time Factors

Substances

  • Acridines
  • Tacrine
  • Oxotremorine
  • 5-Hydroxytryptophan
  • Apomorphine