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The effect of electrospun polycaprolactone scaffold morphology on human kidney epithelial cells.
Burton TP, Corcoran A, Callanan A. Burton TP, et al. Biomed Mater. 2017 Nov 22;13(1):015006. doi: 10.1088/1748-605X/aa8dde. Biomed Mater. 2017. PMID: 29165317
There is a pressing need for further advancement in tissue engineering of functional organs with a view to providing a more clinically relevant model for drug development and reduce the dependence on organ donation. ...Electrospun polymer scaffolds can be cre …
There is a pressing need for further advancement in tissue engineering of functional organs with a view to providing a
From Tension to Compression: Asymmetric Mechanical Behaviour of Trabecular Bone's Organic Phase.
Xie S, Wallace RJ, Callanan A, Pankaj P. Xie S, et al. Ann Biomed Eng. 2018 Jun;46(6):801-809. doi: 10.1007/s10439-018-2009-7. Epub 2018 Mar 27. Ann Biomed Eng. 2018. PMID: 29589168 Free PMC article.
Trabecular bone is a cellular composite material comprising primarily of mineral and organic phases with their content ratio known to change with age. ...We investigated the mechanical response of demineralised bone by subjecting a set of bone samples to fully rever …
Trabecular bone is a cellular composite material comprising primarily of mineral and organic phases with their content ratio known to …
Arrays of 3D double-network hydrogels for the high-throughput discovery of materials with enhanced physical and biological properties.
Duffy C, Venturato A, Callanan A, Lilienkampf A, Bradley M. Duffy C, et al. Acta Biomater. 2016 Apr 1;34:104-112. doi: 10.1016/j.actbio.2015.12.030. Epub 2015 Dec 19. Acta Biomater. 2016. PMID: 26712601
The mechanical properties of hydrogels can be enhanced by the generation of a double-network. Here, we report the development of an array platform that allows the macroscopic synthesis of up to 80 single- and double-network hydrogels on a single microscope slide. Th …
The mechanical properties of hydrogels can be enhanced by the generation of a double-network. Here, we report the development of an a …
A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering.
Burton TP, Callanan A. Burton TP, et al. Among authors: callanan a. Tissue Eng Regen Med. 2018 Feb 14;15(3):301-310. doi: 10.1007/s13770-017-0107-5. eCollection 2018 Jun. Tissue Eng Regen Med. 2018. PMID: 30603555 Free PMC article.
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.
Rashidi H, Luu NT, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM, Chandrashekran A, Dhawan A, Vallier L, Bradley M, Callanan A, Forbes SJ, Newsome PN, Hay DC. Rashidi H, et al. Arch Toxicol. 2018 Oct;92(10):3117-3129. doi: 10.1007/s00204-018-2280-2. Epub 2018 Aug 28. Arch Toxicol. 2018. PMID: 30155720 Free PMC article.
Pluripotent stem cell-derived liver tissue represents a potential alternative to cadaver derived hepatocytes and whole organ transplant. ...
Pluripotent stem cell-derived liver tissue represents a potential alternative to cadaver derived hepatocytes and whole organ transpla …
Secreted Endothelial Cell Factors Immobilized on Collagen Scaffolds Enhance the Recipient Endothelial Cell Environment.
Hamilton C, Callanan A. Hamilton C, et al. Biores Open Access. 2016 Mar 1;5(1):61-71. doi: 10.1089/biores.2016.0003. eCollection 2016. Biores Open Access. 2016. PMID: 27057474 Free PMC article.
Here we utilize this principle from endothelial cells (ECs), to create a novel TE scaffold by harnessing secreted factors and immobilizing these to collagen scaffolds. ...In addition, this process may be a future method utilized to improve other tissue engineering s …
Here we utilize this principle from endothelial cells (ECs), to create a novel TE scaffold by harnessing secreted factors and immobil …
A Drug-Induced Hybrid Electrospun Poly-Capro-Lactone: Cell-Derived Extracellular Matrix Scaffold for Liver Tissue Engineering.
Grant R, Hay DC, Callanan A. Grant R, et al. Tissue Eng Part A. 2017 Jul;23(13-14):650-662. doi: 10.1089/ten.TEA.2016.0419. Epub 2017 May 3. Tissue Eng Part A. 2017. PMID: 28437180
A major challenge for liver tissue engineers is the creation of a hepatocyte microenvironment; a niche in which liver cells can survive and function optimally. ...Our results demonstrate that drug-induced hybrid PCL-ECM scaffolds provide a viable, tran
A major challenge for liver tissue engineers is the creation of a hepatocyte microenvironment; a niche in which liver c
Development of a Bladder Bioreactor for Tissue Engineering in Urology.
Davis NF, Callanan A. Davis NF, et al. Methods Mol Biol. 2016;1502:213-21. doi: 10.1007/7651_2015_309. Methods Mol Biol. 2016. PMID: 26659795
A urinary bladder bioreactor was constructed to replicate physiological bladder dynamics. A cyclical low-delivery pressure regulator mimicked filling pressures of the human bladder. ...
A urinary bladder bioreactor was constructed to replicate physiological bladder dynamics. A cyclical low-delivery pressure reg
Effects of fiber orientation on the frictional properties and damage of regenerative articular cartilage surfaces.
Accardi MA, McCullen SD, Callanan A, Chung S, Cann PM, Stevens MM, Dini D. Accardi MA, et al. Tissue Eng Part A. 2013 Oct;19(19-20):2300-10. doi: 10.1089/ten.TEA.2012.0580. Epub 2013 Jul 27. Tissue Eng Part A. 2013. PMID: 23688110 Free PMC article.
Regenerative medicine strategies offer a promising solution for the treatment of articular cartilage defects and potentially localized early OA. ...Fiber orientation did not significantly affect the equilibrium frictional coefficient, but it was, however, a key fact …
Regenerative medicine strategies offer a promising solution for the treatment of articular cartilage defects and potentially localize …
Anisotropic fibrous scaffolds for articular cartilage regeneration.
McCullen SD, Autefage H, Callanan A, Gentleman E, Stevens MM. McCullen SD, et al. Tissue Eng Part A. 2012 Oct;18(19-20):2073-83. doi: 10.1089/ten.TEA.2011.0606. Epub 2012 Aug 3. Tissue Eng Part A. 2012. PMID: 22655795 Free PMC article.
Fibrous scaffolds offer a template for cartilage extracellular matrix production; however, the success of homogeneous scaffolds is limited by their inability to mimic the cartilage's zone-specific organization and properties. ...Bovine chondrocytes proliferated and produce …
Fibrous scaffolds offer a template for cartilage extracellular matrix production; however, the success of homogeneous scaffolds is li …
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