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Antibiotic resistance is ancient.
D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD. D'Costa VM, et al. Among authors: calmels f. Nature. 2011 Aug 31;477(7365):457-61. doi: 10.1038/nature10388. Nature. 2011. PMID: 21881561