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Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma.

Bower M, Newlands ES, Bleehen NM, Brada M, Begent RJ, Calvert H, Colquhoun I, Lewis P, Brampton MH. Bower M, et al. Among authors: calvert h. Cancer Chemother Pharmacol. 1997;40(6):484-8. doi: 10.1007/s002800050691. Cancer Chemother Pharmacol. 1997. PMID: 9332462 Clinical Trial.

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Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Curtin NJ, Wang LZ, Yiakouvaki A, Kyle S, Arris CA, Canan-Koch S, Webber SE, Durkacz BW, Calvert HA, Hostomsky Z, Newell DR. Curtin NJ, et al. Clin Cancer Res. 2004 Feb 1;10(3):881-9. doi: 10.1158/1078-0432.ccr-1144-3. Clin Cancer Res. 2004. PMID: 14871963

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Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial.

Krug LM, Kindler HL, Calvert H, Manegold C, Tsao AS, Fennell D, Öhman R, Plummer R, Eberhardt WE, Fukuoka K, Gaafar RM, Lafitte JJ, Hillerdal G, Chu Q, Buikhuisen WA, Lubiniecki GM, Sun X, Smith M, Baas P. Krug LM, et al. Among authors: calvert h. Lancet Oncol. 2015 Apr;16(4):447-56. doi: 10.1016/S1470-2045(15)70056-2. Epub 2015 Mar 20. Lancet Oncol. 2015. PMID: 25800891 Clinical Trial.

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A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation.

Plummer R, Lorigan P, Steven N, Scott L, Middleton MR, Wilson RH, Mulligan E, Curtin N, Wang D, Dewji R, Abbattista A, Gallo J, Calvert H. Plummer R, et al. Among authors: calvert h. Cancer Chemother Pharmacol. 2013 May;71(5):1191-9. doi: 10.1007/s00280-013-2113-1. Epub 2013 Feb 20. Cancer Chemother Pharmacol. 2013. PMID: 23423489 Clinical Trial.

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A phase I trial of ZD9331, a water-soluble, nonpolyglutamatable, thymidylate synthase inhibitor.

Plummer R, Rees C, Hughes A, Beale P, Highley M, Trigo J, Gokul S, Judson I, Calvert H, Jackman A, Mitchell F, Smith R, Douglass E. Plummer R, et al. Among authors: calvert h. Clin Cancer Res. 2003 Apr;9(4):1313-22. Clin Cancer Res. 2003. PMID: 12684399 Clinical Trial.

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Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma.

Hughes A, Calvert P, Azzabi A, Plummer R, Johnson R, Rusthoven J, Griffin M, Fishwick K, Boddy AV, Verrill M, Calvert H. Hughes A, et al. Among authors: calvert p, calvert h. J Clin Oncol. 2002 Aug 15;20(16):3533-44. doi: 10.1200/JCO.2002.10.073. J Clin Oncol. 2002. PMID: 12177114

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Future directions in the development of pemetrexed.

Calvert H, Bunn PA Jr. Calvert H, et al. Semin Oncol. 2002 Apr;29(2 Suppl 5):54-61. doi: 10.1053/sonc.2002.30761. Semin Oncol. 2002. PMID: 12023794 Review.

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Performing phase I clinical trials of anticancer agents: perspectives from within the European union and Japan.

Forster MD, Saijo N, Seymour L, Calvert H. Forster MD, et al. Among authors: calvert h. Clin Cancer Res. 2010 Mar 15;16(6):1737-44. doi: 10.1158/1078-0432.CCR-09-2228. Epub 2010 Mar 9. Clin Cancer Res. 2010. PMID: 20215555

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Mechanisms of chemoresistance to alkylating agents in malignant glioma.

Sarkaria JN, Kitange GJ, James CD, Plummer R, Calvert H, Weller M, Wick W. Sarkaria JN, et al. Among authors: calvert h. Clin Cancer Res. 2008 May 15;14(10):2900-8. doi: 10.1158/1078-0432.CCR-07-1719. Clin Cancer Res. 2008. PMID: 18483356 Free PMC article. Review.

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

Plummer R, Jones C, Middleton M, Wilson R, Evans J, Olsen A, Curtin N, Boddy A, McHugh P, Newell D, Harris A, Johnson P, Steinfeldt H, Dewji R, Wang D, Robson L, Calvert H. Plummer R, et al. Among authors: calvert h. Clin Cancer Res. 2008 Dec 1;14(23):7917-23. doi: 10.1158/1078-0432.CCR-08-1223. Clin Cancer Res. 2008. PMID: 19047122 Free PMC article. Clinical Trial.

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