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Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors.
Hava DL, Camilli A. Hava DL, et al. Among authors: camilli a. Mol Microbiol. 2002 Sep;45(5):1389-406. Mol Microbiol. 2002. PMID: 12207705 Free PMC article.
Using signature-tagged mutagenesis to screen 6149 mariner-transposon insertion strains, we identified 387 mutants attenuated for infection in a murine model of pneumonia. ...Included in these strains were two with disruptions in a genetic locus that putatively codes …
Using signature-tagged mutagenesis to screen 6149 mariner-transposon insertion strains, we identified 387 mutants attenuated for infection i …
Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent.
Camilli A, Goldfine H, Portnoy DA. Camilli A, et al. J Exp Med. 1991 Mar 1;173(3):751-4. doi: 10.1084/jem.173.3.751. J Exp Med. 1991. PMID: 1847723 Free PMC article.
A number of bacterial species secrete phosphatidylinositol-specific phospholipase C (PI-PLC). In this report, we show that the facultative intracellular bacterial pathogen, Listeria monocytogenes, contains a gene, plcA, predicting a polypeptide with 31% amino
A number of bacterial species secrete phosphatidylinositol-specific phospholipase C (PI-PLC). In this report, we show that the facult
Use of genetic recombination as a reporter of gene expression.
Camilli A, Beattie DT, Mekalanos JJ. Camilli A, et al. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2634-8. doi: 10.1073/pnas.91.7.2634. Proc Natl Acad Sci U S A. 1994. PMID: 8146167 Free PMC article.
To extend the utility of the reporter gene fusion approach to such studies, we have constructed a gene expression reporter cassette that permits the generation of transcriptional fusions to tnpR encoding resolvase, a site-specific recombinase of the transposable ele …
To extend the utility of the reporter gene fusion approach to such studies, we have constructed a gene expression reporter cassette t …
Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors.
Mahan MJ, Slauch JM, Hanna PC, Camilli A, Tobias JW, Waldor MK, Mekalanos JJ. Mahan MJ, et al. Among authors: camilli a. Infect Agents Dis. 1993 Aug;2(4):263-8. Infect Agents Dis. 1993. PMID: 8173806 Review. No abstract available.
Dual roles of plcA in Listeria monocytogenes pathogenesis.
Camilli A, Tilney LG, Portnoy DA. Camilli A, et al. Mol Microbiol. 1993 Apr;8(1):143-57. doi: 10.1111/j.1365-2958.1993.tb01211.x. Mol Microbiol. 1993. PMID: 8388529 Free PMC article.
Construction of an in-frame deletion within plcA had no effect on expression of prfA thus allowing direct assignment of a role of the Pl-PLC in pathogenesis. Pl-PLC was shown to play a significant role in mediating escape of L. monocytogenes from phagosomes of prima …
Construction of an in-frame deletion within plcA had no effect on expression of prfA thus allowing direct assignment of a role of the …
Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection.
Camilli A, Mekalanos JJ. Camilli A, et al. Mol Microbiol. 1995 Nov;18(4):671-83. doi: 10.1111/j.1365-2958.1995.mmi_18040671.x. Mol Microbiol. 1995. PMID: 8817490 Free PMC article.
We have developed a new screen to identify bacterial genes that are transcriptionally induced during infection of a host animal. The method is based on pre-selection of strains carrying tnpR operon fusions (encoding resolvase, a site-specific DNA recombinase) …
We have developed a new screen to identify bacterial genes that are transcriptionally induced during infection of a host anima …
Noninvasive techniques for studying pathogenic bacteria in the whole animal.
Camilli A. Camilli A. Trends Microbiol. 1996 Aug;4(8):295-6. doi: 10.1016/0966-842x(96)30022-x. Trends Microbiol. 1996. PMID: 8856863 No abstract available.
Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection.
Lee SH, Angelichio MJ, Mekalanos JJ, Camilli A. Lee SH, et al. Among authors: camilli a. J Bacteriol. 1998 May;180(9):2298-305. doi: 10.1128/JB.180.9.2298-2305.1998. J Bacteriol. 1998. PMID: 9573178 Free PMC article.
The iviVII gene of Vibrio cholerae was previously identified by a screen for genes induced during intestinal infection. In the present study, nucleotide sequence analysis revealed that iviVII is a 1,659-bp open reading frame, herein designated vieB, that is predicte …
The iviVII gene of Vibrio cholerae was previously identified by a screen for genes induced during intestinal infection. In the presen …
Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice.
Martinez de Tejada G, Cotter PA, Heininger U, Camilli A, Akerley BJ, Mekalanos JJ, Miller JF. Martinez de Tejada G, et al. Among authors: camilli a. Infect Immun. 1998 Jun;66(6):2762-8. doi: 10.1128/IAI.66.6.2762-2768.1998. Infect Immun. 1998. PMID: 9596745 Free PMC article.
Consistent with this hypothesis was the observation that a B. pertussis mutant, SK6, containing a TnphoA insertion mutation in a Bvg-repressed gene (vrg6) was defective for tracheal and lung colonization in a mouse model of respiratory infection (D. .. …
Consistent with this hypothesis was the observation that a B. pertussis mutant, SK6, containing a TnphoA insertion mutation in …
Systematic identification of essential genes by in vitro mariner mutagenesis.
Akerley BJ, Rubin EJ, Camilli A, Lampe DJ, Robertson HM, Mekalanos JJ. Akerley BJ, et al. Among authors: camilli a. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8927-32. doi: 10.1073/pnas.95.15.8927. Proc Natl Acad Sci U S A. 1998. PMID: 9671781 Free PMC article.
Here, we describe a simple system for performing transposon mutagenesis on naturally transformable organisms along with a technique to rapidly identify essential or conditionally essential DNA segments. ...
Here, we describe a simple system for performing transposon mutagenesis on naturally transformable organisms along with a tech …
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