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Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis.
Cappello F, Caramori G, Campanella C, Vicari C, Gnemmi I, Zanini A, Spanevello A, Capelli A, La Rocca G, Anzalone R, Bucchieri F, D'Anna SE, Ricciardolo FL, Brun P, Balbi B, Carone M, Zummo G, Conway de Macario E, Macario AJ, Di Stefano A. Cappello F, et al. Among authors: campanella c. PLoS One. 2011;6(11):e28200. doi: 10.1371/journal.pone.0028200. Epub 2011 Nov 28. PLoS One. 2011. PMID: 22140545 Free PMC article.
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.
Campanella C, Bucchieri F, Ardizzone NM, Marino Gammazza A, Montalbano A, Ribbene A, Di Felice V, Bellafiore M, David S, Rappa F, Marasà M, Peri G, Farina F, Czarnecka AM, Conway de Macario E, Macario AJ, Zummo G, Cappello F. Campanella C, et al. Eur J Histochem. 2008 Oct-Dec;52(4):221-8. doi: 10.4081/1220. Eur J Histochem. 2008. PMID: 19109096
Hsp60 is actively secreted by human tumor cells.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, Cappello F. Merendino AM, et al. Among authors: campanella c. PLoS One. 2010 Feb 16;5(2):e9247. doi: 10.1371/journal.pone.0009247. PLoS One. 2010. PMID: 20169074 Free PMC article.
The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities.
Campanella C, Bucchieri F, Merendino AM, Fucarino A, Burgio G, Corona DF, Barbieri G, David S, Farina F, Zummo G, de Macario EC, Macario AJ, Cappello F. Campanella C, et al. PLoS One. 2012;7(7):e42008. doi: 10.1371/journal.pone.0042008. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848686 Free PMC article.
207 results