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Hsp60 chaperonopathies and chaperonotherapy: targets and agents.
Cappello F, Marino Gammazza A, Palumbo Piccionello A, Campanella C, Pace A, Conway de Macario E, Macario AJ. Cappello F, et al. Among authors: campanella c. Expert Opin Ther Targets. 2014 Feb;18(2):185-208. doi: 10.1517/14728222.2014.856417. Epub 2013 Nov 29. Expert Opin Ther Targets. 2014. PMID: 24286280 Review.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
Campanella C, Rappa F, Sciumè C, Marino Gammazza A, Barone R, Bucchieri F, David S, Curcurù G, Caruso Bavisotto C, Pitruzzella A, Geraci G, Modica G, Farina F, Zummo G, Fais S, Conway de Macario E, Macario AJ, Cappello F. Campanella C, et al. Cancer. 2015 Sep 15;121(18):3230-9. doi: 10.1002/cncr.29499. Epub 2015 Jun 8. Cancer. 2015. PMID: 26060090 Free article.
Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Marino Gammazza A, Campanella C, Barone R, Caruso Bavisotto C, Gorska M, Wozniak M, Carini F, Cappello F, D'Anneo A, Lauricella M, Zummo G, Conway de Macario E, Macario AJ, Di Felice V. Marino Gammazza A, et al. Among authors: campanella c. Cancer Lett. 2017 Jan 28;385:75-86. doi: 10.1016/j.canlet.2016.10.045. Epub 2016 Nov 9. Cancer Lett. 2017. PMID: 27836734 Free article.
Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
Vilasi S, Carrotta R, Mangione MR, Campanella C, Librizzi F, Randazzo L, Martorana V, Marino Gammazza A, Ortore MG, Vilasi A, Pocsfalvi G, Burgio G, Corona D, Palumbo Piccionello A, Zummo G, Bulone D, Conway de Macario E, Macario AJ, San Biagio PL, Cappello F. Vilasi S, et al. Among authors: campanella c. PLoS One. 2014 May 15;9(5):e97657. doi: 10.1371/journal.pone.0097657. eCollection 2014. PLoS One. 2014. PMID: 24830947 Free PMC article.
The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities.
Campanella C, Bucchieri F, Merendino AM, Fucarino A, Burgio G, Corona DF, Barbieri G, David S, Farina F, Zummo G, de Macario EC, Macario AJ, Cappello F. Campanella C, et al. PLoS One. 2012;7(7):e42008. doi: 10.1371/journal.pone.0042008. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848686 Free PMC article.
Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis.
Cappello F, Caramori G, Campanella C, Vicari C, Gnemmi I, Zanini A, Spanevello A, Capelli A, La Rocca G, Anzalone R, Bucchieri F, D'Anna SE, Ricciardolo FL, Brun P, Balbi B, Carone M, Zummo G, Conway de Macario E, Macario AJ, Di Stefano A. Cappello F, et al. Among authors: campanella c. PLoS One. 2011;6(11):e28200. doi: 10.1371/journal.pone.0028200. Epub 2011 Nov 28. PLoS One. 2011. PMID: 22140545 Free PMC article.
Hsp60 is actively secreted by human tumor cells.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, Cappello F. Merendino AM, et al. Among authors: campanella c. PLoS One. 2010 Feb 16;5(2):e9247. doi: 10.1371/journal.pone.0009247. PLoS One. 2010. PMID: 20169074 Free PMC article.
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Rappa F, Sciume C, Lo Bello M, Bavisotto CC, Marino Gammazza A, Barone R, Campanella C, David S, Carini F, Zarcone F, Rizzuto S, Lena A, Tomasello G, Uzzo ML, Spatola GF, Bonaventura G, Leone A, Gerbino A, Cappello F, Bucchieri F, Zummo G, Farina F. Rappa F, et al. Among authors: campanella c. Anticancer Res. 2014 Aug;34(8):4153-9. Anticancer Res. 2014. PMID: 25075042
197 results