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Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Wilkinson AJ, Ooi N, Finlayson J, Lee VE, Lyth D, Maskew KS, Newman R, Orr D, Ansell K, Birchall K, Canning P, Coombs P, Fusani L, McIver E, Pisco J, Ireland PM, Jenkins C, Norville IH, Southern SJ, Cowan R, Hall G, Kettleborough C, Savage VJ, Cooper IR. Wilkinson AJ, et al. Among authors: canning p. Bioorg Med Chem Lett. 2023 Jun 15;90:129331. doi: 10.1016/j.bmcl.2023.129331. Epub 2023 May 13. Bioorg Med Chem Lett. 2023. PMID: 37187252 Free article.
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
O'Hare M, Esquiva G, McGahon MK, Hombrebueno JMR, Augustine J, Canning P, Edgar KS, Barabas P, Friedel T, Cincolà P, Henry J, Mayne K, Ferrin H, Stitt AW, Lyons TJ, Brazil DP, Grieve DJ, McGeown JG, Curtis TM. O'Hare M, et al. Among authors: canning p. JCI Insight. 2022 Sep 22;7(18):e155128. doi: 10.1172/jci.insight.155128. JCI Insight. 2022. PMID: 36134661 Free PMC article.
100 results