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Transcriptional regulation of cadherins during development and carcinogenesis.
Peinado H, Portillo F, Cano A. Peinado H, et al. Int J Dev Biol. 2004;48(5-6):365-75. doi: 10.1387/ijdb.041794hp. Int J Dev Biol. 2004. PMID: 15349812 Review.
The cadherin superfamily of Ca(2+)-dependent homophilic adhesion molecules plays a critical role in regulating cell-to-cell interactions. ...Indeed, the aberrant expression of cadherins has been detected during carcinoma invasion, a process which is reminiscent of t …
The cadherin superfamily of Ca(2+)-dependent homophilic adhesion molecules plays a critical role in regulating cell-to-cell interacti …
EMT: Present and future in clinical oncology.
Santamaria PG, Moreno-Bueno G, Portillo F, Cano A. Santamaria PG, et al. Mol Oncol. 2017 Jul;11(7):718-738. doi: 10.1002/1878-0261.12091. Epub 2017 Jun 27. Mol Oncol. 2017. PMID: 28590039 Free PMC article. Review.
Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by facilitating tumor cell invasion and dissemination to distant organs. ...However, the translation into the clinics of EMT and epithelial plasticity processes presents enormous challenge …
Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by facilitating tumor cell invasion and dissemin …
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
Cuevas EP, Eraso P, Mazón MJ, Santos V, Moreno-Bueno G, Cano A, Portillo F. Cuevas EP, et al. Sci Rep. 2017 Mar 23;7:44988. doi: 10.1038/srep44988. Sci Rep. 2017. PMID: 28332555 Free PMC article.
Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by activation of different transcription factors collectively known as EMT-TFs. ...Remarkably, perinuclear/cytoplasmic accumulation of LOXL2 is …
Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by a …
Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.
Hergueta-Redondo M, Sarrio D, Molina-Crespo Á, Vicario R, Bernadó-Morales C, Martínez L, Rojo-Sebastián A, Serra-Musach J, Mota A, Martínez-Ramírez Á, Castilla MÁ, González-Martin A, Pernas S, Cano A, Cortes J, Nuciforo PG, Peg V, Palacios J, Pujana MÁ, Arribas J, Moreno-Bueno G. Hergueta-Redondo M, et al. Oncotarget. 2016 Aug 30;7(35):56295-56308. doi: 10.18632/oncotarget.10787. Oncotarget. 2016. PMID: 27462779 Free PMC article.
Interestingly, ERBB2 is frequently co-amplified and co-expressed with neighbour genes that may play a relevant role in this cancer subtype. ...In summary, our data identifies the ERBB2 co-amplified and co-expressed gene GSDMB as a critical determinant of poor progno …
Interestingly, ERBB2 is frequently co-amplified and co-expressed with neighbour genes that may play a relevant role in this cancer su …
Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.
Díaz-López A, Moreno-Bueno G, Cano A. Díaz-López A, et al. Cancer Manag Res. 2014 Apr 25;6:205-16. doi: 10.2147/CMAR.S38156. eCollection 2014. Cancer Manag Res. 2014. PMID: 24812525 Free PMC article. Review.
The microRNAs (miRNAs) are a class of small, 20-22 nucleotides in length, endogenously expressed noncoding RNAs that regulate multiple targets posttranscriptionally. ...Among the most significant feedback loops, we focus on the ZEB/miR-200 and the SNAIL1/miR-34 networks th …
The microRNAs (miRNAs) are a class of small, 20-22 nucleotides in length, endogenously expressed noncoding RNAs that regulate multipl …
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.
Cuevas EP, Moreno-Bueno G, Canesin G, Santos V, Portillo F, Cano A. Cuevas EP, et al. Biol Open. 2014 Feb 15;3(2):129-37. doi: 10.1242/bio.20146841. Biol Open. 2014. PMID: 24414204 Free PMC article.
Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues. ...These findings reveal a non-conventional role of LOXL2 on …
Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the …
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.
Moreno-Bueno G, Salvador F, Martín A, Floristán A, Cuevas EP, Santos V, Montes A, Morales S, Castilla MA, Rojo-Sebastián A, Martínez A, Hardisson D, Csiszar K, Portillo F, Peinado H, Palacios J, Cano A. Moreno-Bueno G, et al. EMBO Mol Med. 2011 Sep;3(9):528-44. doi: 10.1002/emmm.201100156. Epub 2011 Jul 6. EMBO Mol Med. 2011. PMID: 21732535 Free PMC article.
LOXL2 silencing in basal-like carcinoma cells induces a mesenchymal-epithelial transition (MET) associated with a decrease of tumourigenicity and suppression of metastatic potential. ...Therefore, intracellular LOXL2 is a new candidate marker of basal-like ca …
LOXL2 silencing in basal-like carcinoma cells induces a mesenchymal-epithelial transition (MET) associated with a decrease of …
LOXL2 in epithelial cell plasticity and tumor progression.
Cano A, Santamaría PG, Moreno-Bueno G. Cano A, et al. Future Oncol. 2012 Sep;8(9):1095-108. doi: 10.2217/fon.12.105. Future Oncol. 2012. PMID: 23030485 Review.
Secreted LOXL2 participates in the remodeling of the extracellular matrix of the tumor microenvironment, in a similar fashion to prototypical lysyl oxidase. ...
Secreted LOXL2 participates in the remodeling of the extracellular matrix of the tumor microenvironment, in a similar fashion to prot …
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A. Martin A, et al. EMBO J. 2015 Apr 15;34(8):1090-109. doi: 10.15252/embj.201489975. Epub 2015 Mar 10. EMBO J. 2015. PMID: 25759215 Free PMC article.
Lysyl oxidase-like 2 (LOXL2) is involved in a wide range of physiological and pathological processes, including fibrosis and tumor progression, implicating intracellular and extracellular functions. ...Our data identify for the first time novel LOXL2 roles in tissue homeos …
Lysyl oxidase-like 2 (LOXL2) is involved in a wide range of physiological and pathological processes, including fibrosis and tumor pr …
Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.
Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, López-García MÁ, Prat J, Matías-Guiu X, Cano A, Oliva E, Palacios J. Castilla MÁ, et al. J Pathol. 2011 Jan;223(1):72-80. doi: 10.1002/path.2802. Epub 2010 Oct 29. J Pathol. 2011. PMID: 21125666 Clinical Trial.
Endometrial carcinosarcomas (ECSs) undergo a true epithelial-mesenchymal transition (EMT). The molecular determinants of the EMT in vivo are unclear, although a role for some miRNAs, mainly involving the miR-200 family, was recently suggested from in vitro cellular …
Endometrial carcinosarcomas (ECSs) undergo a true epithelial-mesenchymal transition (EMT). The molecular determinants of the EMT in v …
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