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867 results
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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Peinado H, Olmeda D, Cano A. Peinado H, et al. Among authors: cano a. Nat Rev Cancer. 2007 Jun;7(6):415-28. doi: 10.1038/nrc2131. Epub 2007 May 17. Nat Rev Cancer. 2007. PMID: 17508028 Review.
EMT: Present and future in clinical oncology.
Santamaria PG, Moreno-Bueno G, Portillo F, Cano A. Santamaria PG, et al. Among authors: cano a. Mol Oncol. 2017 Jul;11(7):718-738. doi: 10.1002/1878-0261.12091. Epub 2017 Jun 27. Mol Oncol. 2017. PMID: 28590039 Free PMC article. Review.
Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by facilitating tumor cell invasion and dissemination to distant organs. ...However, the translation into the clinics of EMT and epithelial plasticity processes presents enormous challenge …
Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by facilitating tumor cell invasion and dissemin …
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
Cuevas EP, Eraso P, Mazón MJ, Santos V, Moreno-Bueno G, Cano A, Portillo F. Cuevas EP, et al. Among authors: cano a. Sci Rep. 2017 Mar 23;7:44988. doi: 10.1038/srep44988. Sci Rep. 2017. PMID: 28332555 Free PMC article.
Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by activation of different transcription factors collectively known as EMT-TFs. ...Remarkably, perinuclear/cytoplasmic accumulation of LOXL2 is …
Epithelial-to-Mesenchymal Transition (EMT) is a key process contributing to the aggressiveness of cancer cells. EMT is triggered by a …
Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.
Díaz-López A, Moreno-Bueno G, Cano A. Díaz-López A, et al. Among authors: cano a. Cancer Manag Res. 2014 Apr 25;6:205-16. doi: 10.2147/CMAR.S38156. eCollection 2014. Cancer Manag Res. 2014. PMID: 24812525 Free PMC article. Review.
The microRNAs (miRNAs) are a class of small, 20-22 nucleotides in length, endogenously expressed noncoding RNAs that regulate multiple targets posttranscriptionally. ...Among the most significant feedback loops, we focus on the ZEB/miR-200 and the SNAIL1/miR-34 networks th …
The microRNAs (miRNAs) are a class of small, 20-22 nucleotides in length, endogenously expressed noncoding RNAs that regulate multipl …
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.
Cuevas EP, Moreno-Bueno G, Canesin G, Santos V, Portillo F, Cano A. Cuevas EP, et al. Among authors: cano a. Biol Open. 2014 Feb 15;3(2):129-37. doi: 10.1242/bio.20146841. Biol Open. 2014. PMID: 24414204 Free PMC article.
Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the extracellular matrix, thus regulating the tensile strength of tissues. ...These findings reveal a non-conventional role of LOXL2 on …
Lysyl-oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family that catalyzes the cross-linking of collagens or elastins in the …
Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.
Moreno-Bueno G, Salvador F, Martín A, Floristán A, Cuevas EP, Santos V, Montes A, Morales S, Castilla MA, Rojo-Sebastián A, Martínez A, Hardisson D, Csiszar K, Portillo F, Peinado H, Palacios J, Cano A. Moreno-Bueno G, et al. Among authors: cano a. EMBO Mol Med. 2011 Sep;3(9):528-44. doi: 10.1002/emmm.201100156. Epub 2011 Jul 6. EMBO Mol Med. 2011. PMID: 21732535 Free PMC article.
LOXL2 silencing in basal-like carcinoma cells induces a mesenchymal-epithelial transition (MET) associated with a decrease of tumourigenicity and suppression of metastatic potential. ...Therefore, intracellular LOXL2 is a new candidate marker of basal-like ca …
LOXL2 silencing in basal-like carcinoma cells induces a mesenchymal-epithelial transition (MET) associated with a decrease of …
LOXL2 in epithelial cell plasticity and tumor progression.
Cano A, Santamaría PG, Moreno-Bueno G. Cano A, et al. Future Oncol. 2012 Sep;8(9):1095-108. doi: 10.2217/fon.12.105. Future Oncol. 2012. PMID: 23030485 Review.
Secreted LOXL2 participates in the remodeling of the extracellular matrix of the tumor microenvironment, in a similar fashion to prototypical lysyl oxidase. ...
Secreted LOXL2 participates in the remodeling of the extracellular matrix of the tumor microenvironment, in a similar fashion to prot …
Contribution of Epithelial Plasticity to Therapy Resistance.
Santamaría PG, Moreno-Bueno G, Cano A. Santamaría PG, et al. Among authors: cano a. J Clin Med. 2019 May 14;8(5):676. doi: 10.3390/jcm8050676. J Clin Med. 2019. PMID: 31091749 Free PMC article. Review.
Unfortunately, in too many cases, resistance reappears leading to a fatal outcome. The recent introduction of immunotherapy regimes has provided an unprecedented success in the treatment of specific cancer types; however, a good percentage of patients do not respond …
Unfortunately, in too many cases, resistance reappears leading to a fatal outcome. The recent introduction of immunotherapy regimes h …
Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.
Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, López-García MÁ, Prat J, Matías-Guiu X, Cano A, Oliva E, Palacios J. Castilla MÁ, et al. Among authors: cano a. J Pathol. 2011 Jan;223(1):72-80. doi: 10.1002/path.2802. Epub 2010 Oct 29. J Pathol. 2011. PMID: 21125666
Endometrial carcinosarcomas (ECSs) undergo a true epithelial-mesenchymal transition (EMT). The molecular determinants of the EMT in vivo are unclear, although a role for some miRNAs, mainly involving the miR-200 family, was recently suggested from in vitro cellular …
Endometrial carcinosarcomas (ECSs) undergo a true epithelial-mesenchymal transition (EMT). The molecular determinants of the EMT in v …
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.
Fraga MF, Herranz M, Espada J, Ballestar E, Paz MF, Ropero S, Erkek E, Bozdogan O, Peinado H, Niveleau A, Mao JH, Balmain A, Cano A, Esteller M. Fraga MF, et al. Among authors: cano a. Cancer Res. 2004 Aug 15;64(16):5527-34. doi: 10.1158/0008-5472.CAN-03-4061. Cancer Res. 2004. PMID: 15313885
Paradoxically, this occurs in the context of a growing number of hypermethylated CpG islands of tumor suppressor genes at the most malignant stages of carcinogenesis. We have observed this last phenomenon using two approaches, a candidate gene approach, studying gen …
Paradoxically, this occurs in the context of a growing number of hypermethylated CpG islands of tumor suppressor genes at the most ma …
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