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Mitochondrial toxins and neurodegenerative diseases.
Ayala A, Venero JL, Cano J, Machado A. Ayala A, et al. Among authors: cano j. Front Biosci. 2007 Jan 1;12:986-1007. doi: 10.2741/2119. Front Biosci. 2007. PMID: 17127354 Review.
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients.
Burguillos MA, Hajji N, Englund E, Persson A, Cenci AM, Machado A, Cano J, Joseph B, Venero JL. Burguillos MA, et al. Among authors: cano j. Neurobiol Dis. 2011 Jan;41(1):177-88. doi: 10.1016/j.nbd.2010.09.005. Epub 2010 Sep 17. Neurobiol Dis. 2011. PMID: 20850531
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma.
Castaño A, Herrera AJ, Cano J, Machado A. Castaño A, et al. Among authors: cano j. J Neurochem. 2002 Apr;81(1):150-7. doi: 10.1046/j.1471-4159.2002.00799.x. J Neurochem. 2002. PMID: 12067227
Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction.
Matarredona ER, Santiago M, Venero JL, Cano J, Machado A. Matarredona ER, et al. Among authors: cano j. J Neurochem. 2001 Jan;76(2):351-60. doi: 10.1046/j.1471-4159.2001.00056.x. J Neurochem. 2001. PMID: 11208898
The endogenous amine 1-methyl-1,2,3,4- tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP(+).
Parrado J, Absi E, Ayala A, Castaño A, Cano J, Machado A. Parrado J, et al. Among authors: cano j. J Neurochem. 2000 Jul;75(1):65-71. doi: 10.1046/j.1471-4159.2000.0750065.x. J Neurochem. 2000. PMID: 10854248
Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes.
Bougria M, Vitorica J, Cano J, Machado A. Bougria M, et al. Among authors: cano j. Eur J Pharmacol. 1995 Nov 30;291(3):407-15. doi: 10.1016/0922-4106(95)90083-7. Eur J Pharmacol. 1995. PMID: 8719427
Complex I inhibitor effect on the nigral and striatal release of dopamine in the presence and absence of nomifensine.
Santiago M, Granero L, Machado A, Cano J. Santiago M, et al. Among authors: cano j. Eur J Pharmacol. 1995 Jul 14;280(3):251-6. doi: 10.1016/0014-2999(95)00202-v. Eur J Pharmacol. 1995. PMID: 8566093
1-Methyl-4-phenylpyridinium has greater neurotoxic effect after selenium deficiency than after vitamin E deficiency in rat striatum.
Vizuete ML, Steffen V, Machado A, Cano J. Vizuete ML, et al. Among authors: cano j. Eur J Pharmacol. 1994 Apr 4;270(2-3):183-7. doi: 10.1016/0926-6917(94)90061-2. Eur J Pharmacol. 1994. PMID: 8039547
Stress increases vulnerability to inflammation in the rat prefrontal cortex.
de Pablos RM, Villarán RF, Argüelles S, Herrera AJ, Venero JL, Ayala A, Cano J, Machado A. de Pablos RM, et al. Among authors: cano j. J Neurosci. 2006 May 24;26(21):5709-19. doi: 10.1523/JNEUROSCI.0802-06.2006. J Neurosci. 2006. PMID: 16723527 Free PMC article.
Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.
Santiago M, Hernández-Romero MC, Machado A, Cano J. Santiago M, et al. Among authors: cano j. Eur J Pharmacol. 2009 May 1;609(1-3):58-64. doi: 10.1016/j.ejphar.2009.03.026. Epub 2009 Mar 16. Eur J Pharmacol. 2009. PMID: 19292984
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