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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. Cantó C, et al. Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813. Nature. 2009. PMID: 19262508 Free PMC article.
Caloric restriction, SIRT1 and longevity.
Cantó C, Auwerx J. Cantó C, et al. Trends Endocrinol Metab. 2009 Sep;20(7):325-31. doi: 10.1016/j.tem.2009.03.008. Epub 2009 Aug 25. Trends Endocrinol Metab. 2009. PMID: 19713122 Free PMC article. Review.
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
Houtkooper RH, Cantó C, Wanders RJ, Auwerx J. Houtkooper RH, et al. Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9. Endocr Rev. 2010. PMID: 20007326 Free PMC article. Review.
Clking on PGC-1alpha to inhibit gluconeogenesis.
Cantó C, Auwerx J. Cantó C, et al. Cell Metab. 2010 Jan;11(1):6-7. doi: 10.1016/j.cmet.2009.12.003. Cell Metab. 2010. PMID: 20085730 Free PMC article.
AMP-activated protein kinase and its downstream transcriptional pathways.
Cantó C, Auwerx J. Cantó C, et al. Cell Mol Life Sci. 2010 Oct;67(20):3407-23. doi: 10.1007/s00018-010-0454-z. Epub 2010 Jul 17. Cell Mol Life Sci. 2010. PMID: 20640476 Free PMC article. Review.
PARP-2 regulates SIRT1 expression and whole-body energy expenditure.
Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. Bai P, et al. Cell Metab. 2011 Apr 6;13(4):450-460. doi: 10.1016/j.cmet.2011.03.013. Cell Metab. 2011. PMID: 21459329 Free PMC article.
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. Bai P, et al. Cell Metab. 2011 Apr 6;13(4):461-468. doi: 10.1016/j.cmet.2011.03.004. Cell Metab. 2011. PMID: 21459330 Free PMC article.
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
Cantó C, Auwerx J. Cantó C, et al. Aging (Albany NY). 2011 May;3(5):543-7. doi: 10.18632/aging.100326. Aging (Albany NY). 2011. PMID: 21566260 Free PMC article.
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