Cantley LC - Search Results

1

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Carracedo A, et al. Among authors: cantley lc. J Clin Invest. 2008 Sep;118(9):3065-74. doi: 10.1172/JCI34739. J Clin Invest. 2008. PMID: 18725988 Free PMC article.

2

Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts.

Ma L, Cantley LC, Janmey PA, Kirschner MW. Ma L, et al. Among authors: cantley lc. J Cell Biol. 1998 Mar 9;140(5):1125-36. doi: 10.1083/jcb.140.5.1125. J Cell Biol. 1998. PMID: 9490725 Free PMC article.

3

Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.

Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML. Singh VP, et al. Among authors: cantley lc. J Clin Invest. 2001 Nov;108(9):1387-95. doi: 10.1172/JCI12874. J Clin Invest. 2001. PMID: 11696584 Free PMC article.

4

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Mauvais-Jarvis F, et al. Among authors: cantley lc. J Clin Invest. 2002 Jan;109(1):141-9. doi: 10.1172/JCI13305. J Clin Invest. 2002. PMID: 11781359 Free PMC article.

5

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Manning BD, et al. Among authors: cantley lc. Genes Dev. 2005 Aug 1;19(15):1773-8. doi: 10.1101/gad.1314605. Epub 2005 Jul 18. Genes Dev. 2005. PMID: 16027169 Free PMC article.

6

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.

Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, Jänne PA. Engelman JA, et al. Among authors: cantley lc. J Clin Invest. 2006 Oct;116(10):2695-706. doi: 10.1172/JCI28656. Epub 2006 Aug 10. J Clin Invest. 2006. PMID: 16906227 Free PMC article.

7

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Gewinner C, et al. Among authors: cantley lc. Cancer Cell. 2009 Aug 4;16(2):115-25. doi: 10.1016/j.ccr.2009.06.006. Cancer Cell. 2009. PMID: 19647222 Free PMC article.

8

Targeting the PI3K signaling pathway in cancer.

Wong KK, Engelman JA, Cantley LC. Wong KK, et al. Among authors: cantley lc. Curr Opin Genet Dev. 2010 Feb;20(1):87-90. doi: 10.1016/j.gde.2009.11.002. Epub 2009 Dec 16. Curr Opin Genet Dev. 2010. PMID: 20006486 Free PMC article. Review.

9

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Sasaki AT, et al. Among authors: cantley lc. Sci Signal. 2011 Mar 8;4(163):ra13. doi: 10.1126/scisignal.2001518. Sci Signal. 2011. PMID: 21386094 Free PMC article.

10

A fluorescent reporter of AMPK activity and cellular energy stress.

Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. Tsou P, et al. Among authors: cantley lc. Cell Metab. 2011 Apr 6;13(4):476-486. doi: 10.1016/j.cmet.2011.03.006. Cell Metab. 2011. PMID: 21459332 Free PMC article.

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