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CysLT1 signal transduction in differentiated U937 cells involves the activation of the small GTP-binding protein Ras.
Capra V, Ravasi S, Accomazzo MR, Parenti M, Rovati GE. Capra V, et al. Biochem Pharmacol. 2004 Apr 15;67(8):1569-77. doi: 10.1016/j.bcp.2003.12.027. Biochem Pharmacol. 2004. PMID: 15041474
Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Capra V, Carnini C, Accomazzo MR, Di Gennaro A, Fiumicelli M, Borroni E, Brivio I, Buccellati C, Mangano P, Carnevali S, Rovati G, Sala A. Capra V, et al. Prostaglandins Other Lipid Mediat. 2015 Jul;120:115-25. doi: 10.1016/j.prostaglandins.2015.03.007. Epub 2015 Apr 1. Prostaglandins Other Lipid Mediat. 2015. PMID: 25839425
The DRY motif and the four corners of the cubic ternary complex model.
Rovati GE, Capra V, Shaw VS, Malik RU, Sivaramakrishnan S, Neubig RR. Rovati GE, et al. Among authors: capra v. Cell Signal. 2017 Jul;35:16-23. doi: 10.1016/j.cellsig.2017.03.020. Epub 2017 Mar 24. Cell Signal. 2017. PMID: 28347873 Review.
The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.
Rovati GE, Capra V, Neubig RR. Rovati GE, et al. Among authors: capra v. Mol Pharmacol. 2007 Apr;71(4):959-64. doi: 10.1124/mol.106.029470. Epub 2006 Dec 27. Mol Pharmacol. 2007. PMID: 17192495 Review.
Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation.
Capra V, Busnelli M, Perenna A, Ambrosio M, Accomazzo MR, Galés C, Chini B, Rovati GE. Capra V, et al. PLoS One. 2013;8(3):e60475. doi: 10.1371/journal.pone.0060475. Epub 2013 Mar 28. PLoS One. 2013. PMID: 23555978 Free PMC article.
Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants.
Ambrosio M, Fanelli F, Brocchetti S, Raimondi F, Mauri M, Rovati GE, Capra V. Ambrosio M, et al. Among authors: capra v. Cell Mol Life Sci. 2010 Sep;67(17):2979-89. doi: 10.1007/s00018-010-0368-9. Epub 2010 Apr 11. Cell Mol Life Sci. 2010. PMID: 20383734
A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes.
Capra V, Accomazzo MR, Gardoni F, Barbieri S, Rovati GE. Capra V, et al. J Lipid Res. 2010 May;51(5):1075-84. doi: 10.1194/jlr.M003236. Epub 2009 Nov 15. J Lipid Res. 2010. PMID: 19965602 Free PMC article.
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Mamedova L, Capra V, Accomazzo MR, Gao ZG, Ferrario S, Fumagalli M, Abbracchio MP, Rovati GE, Jacobson KA. Mamedova L, et al. Among authors: capra v. Biochem Pharmacol. 2005 Dec 19;71(1-2):115-25. doi: 10.1016/j.bcp.2005.10.003. Epub 2005 Nov 8. Biochem Pharmacol. 2005. PMID: 16280122 Free PMC article.
CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation.
Ravasi S, Citro S, Viviani B, Capra V, Rovati GE. Ravasi S, et al. Among authors: capra v. Respir Res. 2006 Mar 22;7(1):42. doi: 10.1186/1465-9921-7-42. Respir Res. 2006. PMID: 16553950 Free PMC article.
Cysteinyl-leukotriene receptors and cellular signals.
Rovati GE, Capra V. Rovati GE, et al. Among authors: capra v. ScientificWorldJournal. 2007 Sep 1;7:1375-92. doi: 10.1100/tsw.2007.185. ScientificWorldJournal. 2007. PMID: 17767356 Free PMC article. Review.
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