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Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly.
Olivieri F, Antonicelli R, Cardelli M, Marchegiani F, Cavallone L, Mocchegiani E, Franceschi C. Olivieri F, et al. Mech Ageing Dev. 2006 Jun;127(6):552-9. doi: 10.1016/j.mad.2006.01.013. Epub 2006 Mar 6. Mech Ageing Dev. 2006. PMID: 16516951 Review.
A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.
Bonafè M, Olivieri F, Cavallone L, Giovagnetti S, Mayegiani F, Cardelli M, Pieri C, Marra M, Antonicelli R, Lisa R, Rizzo MR, Paolisso G, Monti D, Franceschi C. Bonafè M, et al. Eur J Immunol. 2001 Aug;31(8):2357-61. doi: 10.1002/1521-4141(200108)31:8<2357::aid-immu2357>3.0.co;2-x. Eur J Immunol. 2001. PMID: 11500818
The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.
Olivieri F, Bonafè M, Cavallone L, Giovagnetti S, Marchegiani F, Cardelli M, Mugianesi E, Giampieri C, Moresi R, Stecconi R, Lisa R, Franceschi C. Olivieri F, et al. Exp Gerontol. 2002 Jan-Mar;37(2-3):309-14. doi: 10.1016/s0531-5565(01)00197-8. Exp Gerontol. 2002. PMID: 11772517
The role of IL-1 gene cluster in longevity: a study in Italian population.
Cavallone L, Bonafè M, Olivieri F, Cardelli M, Marchegiani F, Giovagnetti S, Di Stasio G, Giampieri C, Mugianesi E, Stecconi R, Sciacca F, Grimaldi LM, De Benedictis G, Lio D, Caruso C, Franceschi C. Cavallone L, et al. Mech Ageing Dev. 2003 Apr;124(4):533-8. doi: 10.1016/s0047-6374(03)00033-2. Mech Ageing Dev. 2003. PMID: 12714264
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C. Olivieri F, et al. Mech Ageing Dev. 2003 Apr;124(4):549-53. doi: 10.1016/s0047-6374(03)00035-6. Mech Ageing Dev. 2003. PMID: 12714266
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.
Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Stecconi R, Molendini C, Trapassi C, De Benedictis G, Kletsas D, Franceschi C. Carrieri G, et al. Aging Cell. 2004 Dec;3(6):443-8. doi: 10.1111/j.1474-9728.2004.00129.x. Aging Cell. 2004. PMID: 15569360
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D. Franceschi C, et al. Mech Ageing Dev. 2005 Feb;126(2):351-61. doi: 10.1016/j.mad.2004.08.028. Mech Ageing Dev. 2005. PMID: 15621218 Review.
The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients.
Antonicelli R, Olivieri F, Bonafè M, Cavallone L, Spazzafumo L, Marchegiani F, Cardelli M, Recanatini A, Testarmata P, Boemi M, Parati G, Franceschi C. Antonicelli R, et al. Int J Cardiol. 2005 Sep 1;103(3):266-71. doi: 10.1016/j.ijcard.2004.08.064. Int J Cardiol. 2005. PMID: 16098388
Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers.
Antonicelli R, Olivieri F, Cavallone L, Spazzafumo L, Bonafè M, Marchegiani F, Cardelli M, Galeazzi R, Giovagnetti S, Perna GP, Franceschi C. Antonicelli R, et al. Coron Artery Dis. 2005 Dec;16(8):489-93. doi: 10.1097/00019501-200512000-00006. Coron Artery Dis. 2005. PMID: 16319659
Paraoxonase activity and genotype predispose to successful aging.
Marchegiani F, Marra M, Spazzafumo L, James RW, Boemi M, Olivieri F, Cardelli M, Cavallone L, Bonfigli AR, Franceschi C. Marchegiani F, et al. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):541-6. doi: 10.1093/gerona/61.6.541. J Gerontol A Biol Sci Med Sci. 2006. PMID: 16799134
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