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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
Cardenas ME, Heitman J. Cardenas ME, et al. EMBO J. 1995 Dec 1;14(23):5892-907. EMBO J. 1995. PMID: 8846782 Free PMC article.
Casein kinase II phosphorylates the eukaryote-specific C-terminal domain of topoisomerase II in vivo.
Cardenas ME, Dang Q, Glover CV, Gasser SM. Cardenas ME, et al. EMBO J. 1992 May;11(5):1785-96. EMBO J. 1992. PMID: 1316274 Free PMC article.
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
Breuder T, Hemenway CS, Movva NR, Cardenas ME, Heitman J. Breuder T, et al. Among authors: cardenas me. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5372-6. doi: 10.1073/pnas.91.12.5372. Proc Natl Acad Sci U S A. 1994. PMID: 7515500 Free PMC article.
Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
Heitman J, Cardenas ME, Breuder T, Hemenway C, Muir RS, Lim E, Goetz L, Zhu D, Lorenz M, Dolinski K. Heitman J, et al. Among authors: cardenas me. Transplant Proc. 1994 Oct;26(5):2833-4. Transplant Proc. 1994. PMID: 7524220 No abstract available.
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
Cardenas ME, Hemenway C, Muir RS, Ye R, Fiorentino D, Heitman J. Cardenas ME, et al. EMBO J. 1994 Dec 15;13(24):5944-57. EMBO J. 1994. PMID: 7529175 Free PMC article.
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
Cardenas ME, Muir RS, Breuder T, Heitman J. Cardenas ME, et al. EMBO J. 1995 Jun 15;14(12):2772-83. EMBO J. 1995. PMID: 7540976 Free PMC article.
Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
Zhu D, Cardenas ME, Heitman J. Zhu D, et al. Among authors: cardenas me. J Biol Chem. 1995 Oct 20;270(42):24831-8. doi: 10.1074/jbc.270.42.24831. J Biol Chem. 1995. PMID: 7559604
Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
Cardenas ME, Lim E, Heitman J. Cardenas ME, et al. J Biol Chem. 1995 Sep 8;270(36):20997-1002. doi: 10.1074/jbc.270.36.20997. J Biol Chem. 1995. PMID: 7673124
vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.
Hemenway CS, Dolinski K, Cardenas ME, Hiller MA, Jones EW, Heitman J. Hemenway CS, et al. Among authors: cardenas me. Genetics. 1995 Nov;141(3):833-44. Genetics. 1995. PMID: 8582630 Free PMC article.
Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
Cardenas ME, Zhu D, Heitman J. Cardenas ME, et al. Curr Opin Nephrol Hypertens. 1995 Nov;4(6):472-7. doi: 10.1097/00041552-199511000-00002. Curr Opin Nephrol Hypertens. 1995. PMID: 8591053 Review.
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