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Association study designs for complex diseases.
Cardon LR, Bell JI. Cardon LR, et al. Nat Rev Genet. 2001 Feb;2(2):91-9. doi: 10.1038/35052543. Nat Rev Genet. 2001. PMID: 11253062 Review.
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT. Zeggini E, et al. Science. 2007 Jun 1;316(5829):1336-41. doi: 10.1126/science.1142364. Epub 2007 Apr 26. Science. 2007. PMID: 17463249 Free PMC article.
Functional epistasis on a common MHC haplotype associated with multiple sclerosis.
Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen AR, Cardon LR, Bell JI, Fugger L. Gregersen JW, et al. Nature. 2006 Oct 5;443(7111):574-7. doi: 10.1038/nature05133. Epub 2006 Sep 27. Nature. 2006. PMID: 17006452
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C. van Heel DA, et al. Nat Genet. 2007 Jul;39(7):827-9. doi: 10.1038/ng2058. Epub 2007 Jun 10. Nat Genet. 2007. PMID: 17558408 Free PMC article.
Finding the missing heritability of complex diseases.
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Manolio TA, et al. Nature. 2009 Oct 8;461(7265):747-53. doi: 10.1038/nature08494. Nature. 2009. PMID: 19812666 Free PMC article. Review.
The support of human genetic evidence for approved drug indications.
Nelson MR, Tipney H, Painter JL, Shen J, Nicoletti P, Shen Y, Floratos A, Sham PC, Li MJ, Wang J, Cardon LR, Whittaker JC, Sanseau P. Nelson MR, et al. Among authors: cardon lr. Nat Genet. 2015 Aug;47(8):856-60. doi: 10.1038/ng.3314. Epub 2015 Jun 29. Nat Genet. 2015. PMID: 26121088
A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults.
Millwood IY, Bennett DA, Walters RG, Clarke R, Waterworth D, Johnson T, Chen Y, Yang L, Guo Y, Bian Z, Hacker A, Yeo A, Parish S, Hill MR, Chissoe S, Peto R, Cardon L, Collins R, Li L, Chen Z; China Kadoorie Biobank Collaborative Group. Millwood IY, et al. Int J Epidemiol. 2016 Oct;45(5):1588-1599. doi: 10.1093/ije/dyw087. Epub 2016 Jun 14. Int J Epidemiol. 2016. PMID: 27301456 Free PMC article.
Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.
Clarke R, Xu P, Bennett D, Lewington S, Zondervan K, Parish S, Palmer A, Clark S, Cardon L, Peto R, Lathrop M, Collins R; International Study of Infarct Survival (ISIS) Collaborators. Clarke R, et al. PLoS Genet. 2006 Jul;2(7):e107. doi: 10.1371/journal.pgen.0020107. PLoS Genet. 2006. PMID: 16839190 Free PMC article.
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.
Zhang Y, Leaves NI, Anderson GG, Ponting CP, Broxholme J, Holt R, Edser P, Bhattacharyya S, Dunham A, Adcock IM, Pulleyn L, Barnes PJ, Harper JI, Abecasis G, Cardon L, White M, Burton J, Matthews L, Mott R, Ross M, Cox R, Moffatt MF, Cookson WO. Zhang Y, et al. Nat Genet. 2003 Jun;34(2):181-6. doi: 10.1038/ng1166. Nat Genet. 2003. PMID: 12754510
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