Carlier PR - Search Results

1

Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Rydberg EH, et al. Among authors: carlier pr. J Med Chem. 2006 Sep 7;49(18):5491-500. doi: 10.1021/jm060164b. J Med Chem. 2006. PMID: 16942022

2

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Wong DM, et al. Among authors: carlier pr. J Am Chem Soc. 2003 Jan 15;125(2):363-73. doi: 10.1021/ja021111w. J Am Chem Soc. 2003. PMID: 12517147

3

Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.

Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. Haviv H, et al. Among authors: carlier pr. J Am Chem Soc. 2005 Aug 10;127(31):11029-36. doi: 10.1021/ja051765f. J Am Chem Soc. 2005. PMID: 16076210

4

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

Carlier PR, Du DM, Han Y, Liu J, Pang YP. Carlier PR, et al. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2335-8. doi: 10.1016/s0960-894x(99)00396-0. Bioorg Med Chem Lett. 1999. PMID: 10476864

5

Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.

Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP. Carlier PR, et al. J Med Chem. 1999 Oct 7;42(20):4225-31. doi: 10.1021/jm990224w. J Med Chem. 1999. PMID: 10514292

6

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR. Han YF, et al. Among authors: carlier pr. Bioorg Med Chem. 1999 Nov;7(11):2569-75. doi: 10.1016/s0968-0896(99)00178-9. Bioorg Med Chem. 1999. PMID: 10632067

7

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.

Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP. Carlier PR, et al. Bioorg Med Chem. 1999 Feb;7(2):351-7. doi: 10.1016/s0968-0896(98)00213-2. Bioorg Med Chem. 1999. PMID: 10218828

8

Catalytic asymmetric synthesis of protected tryptophan regioisomers.

Carlier PR, Lam PC, Wong DM. Carlier PR, et al. J Org Chem. 2002 Aug 23;67(17):6256-9. doi: 10.1021/jo025964i. J Org Chem. 2002. PMID: 12182675

9

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Hartsel JA, et al. Among authors: carlier pr. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22738634 Free PMC article.

10

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.

Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KW, Li M, Han Y. Li W, et al. Among authors: carlier pr. J Biol Chem. 2005 May 6;280(18):18179-88. doi: 10.1074/jbc.M411085200. Epub 2005 Feb 14. J Biol Chem. 2005. PMID: 15710623 Free article.

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