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Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.
Carlile DJ, Hakooz N, Bayliss MK, Houston JB. Carlile DJ, et al. Br J Clin Pharmacol. 1999 Jun;47(6):625-35. doi: 10.1046/j.1365-2125.1999.00935.x. Br J Clin Pharmacol. 1999. PMID: 10383540 Free PMC article.
Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance.
Hakooz N, Ito K, Rawden H, Gill H, Lemmers L, Boobis AR, Edwards RJ, Carlile DJ, Lake BG, Houston JB. Hakooz N, et al. Among authors: carlile dj. Pharm Res. 2006 Mar;23(3):533-9. doi: 10.1007/s11095-006-9531-2. Epub 2006 Feb 28. Pharm Res. 2006. PMID: 16505976
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A. Barter ZE, et al. Among authors: carlile dj. Curr Drug Metab. 2007 Jan;8(1):33-45. doi: 10.2174/138920007779315053. Curr Drug Metab. 2007. PMID: 17266522 Review.
Population pharmacokinetics of the MEK inhibitor selumetinib and its active N-desmethyl metabolite: data from 10 phase I trials.
Patel P, Howgate E, Martin P, Carlile DJ, Aarons L, Zhou D. Patel P, et al. Among authors: carlile dj. Br J Clin Pharmacol. 2018 Jan;84(1):52-63. doi: 10.1111/bcp.13404. Epub 2017 Sep 22. Br J Clin Pharmacol. 2018. PMID: 28833380 Free PMC article.
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.
Andrews J, Abd-Ellah MF, Randolph NL, Kenworthy KE, Carlile DJ, Friedberg T, Houston JB. Andrews J, et al. Among authors: carlile dj. Xenobiotica. 2002 Nov;32(11):937-47. doi: 10.1080/00498250210163289. Xenobiotica. 2002. PMID: 12487724
Incorporation of in vitro drug metabolism data into physiologically-based pharmacokinetic models.
Houston JB, Carlile DJ. Houston JB, et al. Among authors: carlile dj. Toxicol In Vitro. 1997 Oct;11(5):473-8. doi: 10.1016/s0887-2333(97)00056-8. Toxicol In Vitro. 1997. PMID: 20654337
Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans.
Rawden HC, Carlile DJ, Tindall A, Hallifax D, Galetin A, Ito K, Houston JB. Rawden HC, et al. Among authors: carlile dj. Xenobiotica. 2005 Jun;35(6):603-25. doi: 10.1080/00498250500162870. Xenobiotica. 2005. PMID: 16192111
In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes.
Carlile DJ, Stevens AJ, Ashforth EI, Waghela D, Houston JB. Carlile DJ, et al. Drug Metab Dispos. 1998 Mar;26(3):216-21. Drug Metab Dispos. 1998. PMID: 9492383
Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices.
Houston JB, Carlile DJ. Houston JB, et al. Among authors: carlile dj. Drug Metab Rev. 1997 Nov;29(4):891-922. doi: 10.3109/03602539709002237. Drug Metab Rev. 1997. PMID: 9421679 Review. No abstract available.
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