Carlile DJ - Search Results

1

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices.

Houston JB, Carlile DJ. Houston JB, et al. Among authors: carlile dj. Drug Metab Rev. 1997 Nov;29(4):891-922. doi: 10.3109/03602539709002237. Drug Metab Rev. 1997. PMID: 9421679 Review. No abstract available.

2

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance.

Hakooz N, Ito K, Rawden H, Gill H, Lemmers L, Boobis AR, Edwards RJ, Carlile DJ, Lake BG, Houston JB. Hakooz N, et al. Among authors: carlile dj. Pharm Res. 2006 Mar;23(3):533-9. doi: 10.1007/s11095-006-9531-2. Epub 2006 Feb 28. Pharm Res. 2006. PMID: 16505976

3

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A. Barter ZE, et al. Among authors: carlile dj. Curr Drug Metab. 2007 Jan;8(1):33-45. doi: 10.2174/138920007779315053. Curr Drug Metab. 2007. PMID: 17266522 Review.

4

Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.

Andrews J, Abd-Ellah MF, Randolph NL, Kenworthy KE, Carlile DJ, Friedberg T, Houston JB. Andrews J, et al. Among authors: carlile dj. Xenobiotica. 2002 Nov;32(11):937-47. doi: 10.1080/00498250210163289. Xenobiotica. 2002. PMID: 12487724

5

Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans.

Rawden HC, Carlile DJ, Tindall A, Hallifax D, Galetin A, Ito K, Houston JB. Rawden HC, et al. Among authors: carlile dj. Xenobiotica. 2005 Jun;35(6):603-25. doi: 10.1080/00498250500162870. Xenobiotica. 2005. PMID: 16192111

6

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans.

Carlile DJ, Hakooz N, Bayliss MK, Houston JB. Carlile DJ, et al. Br J Clin Pharmacol. 1999 Jun;47(6):625-35. doi: 10.1046/j.1365-2125.1999.00935.x. Br J Clin Pharmacol. 1999. PMID: 10383540 Free PMC article.

7

Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.

Carlile DJ, Hakooz N, Houston JB. Carlile DJ, et al. Drug Metab Dispos. 1999 Apr;27(4):526-32. Drug Metab Dispos. 1999. PMID: 10101148

8

In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes.

Carlile DJ, Stevens AJ, Ashforth EI, Waghela D, Houston JB. Carlile DJ, et al. Drug Metab Dispos. 1998 Mar;26(3):216-21. Drug Metab Dispos. 1998. PMID: 9492383

9

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

Carlile DJ, Zomorodi K, Houston JB. Carlile DJ, et al. Drug Metab Dispos. 1997 Aug;25(8):903-11. Drug Metab Dispos. 1997. PMID: 9280396

10

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data.

Ashforth EI, Carlile DJ, Chenery R, Houston JB. Ashforth EI, et al. Among authors: carlile dj. J Pharmacol Exp Ther. 1995 Aug;274(2):761-6. J Pharmacol Exp Ther. 1995. PMID: 7636740

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