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Page 1
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. Yoneshiro T, et al. Nature. 2019 Aug;572(7771):614-619. doi: 10.1038/s41586-019-1503-x. Epub 2019 Aug 21. Nature. 2019. PMID: 31435015 Free PMC article.
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat.
Brunetta HS, Jung AS, Valdivieso-Rivera F, de Campos Zani SC, Guerra J, Furino VO, Francisco A, Berçot M, Moraes-Vieira PM, Keipert S, Jastroch M, Martinez LO, Sponton CH, Castilho RF, Mori MA, Bartelt A. Brunetta HS, et al. Among authors: sponton ch. EMBO J. 2024 Nov;43(21):4870-4891. doi: 10.1038/s44318-024-00215-0. Epub 2024 Sep 16. EMBO J. 2024. PMID: 39284909 Free PMC article.
Balb/c mice are protected from glucose and acute cold intolerance.
Simoes MR, Bombassaro B, Gallo-Ferraz AL, Nogueira PAS, Monfort-Pires M, Zanesco AM, Valdivieso-Rivera F, Nogueira GAS, Sponton CH, Castilho RF, Velloso LA. Simoes MR, et al. Among authors: sponton ch. Biochim Biophys Acta Mol Basis Dis. 2025 Jun;1871(5):167725. doi: 10.1016/j.bbadis.2025.167725. Epub 2025 Feb 27. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 40023454
Bidirectional shifts in Pm20d1 expression impact thermogenesis and metabolism.
Simoes MR, Gallo-Ferraz AL, Bombassaro B, Valdivieso-Rivera F, Nogueira GAS, Monfort-Pires M, da Cruz MV, Zanesco AM, Fernanda-Oliveira N, Silveira LR, Castilho RF, Sponton CH, Velloso LA. Simoes MR, et al. Among authors: sponton ch. Mol Med. 2025 Aug 28;31(1):283. doi: 10.1186/s10020-025-01345-9. Mol Med. 2025. PMID: 40877813 Free PMC article.
Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle.
Lima TI, Araujo HN, Menezes ES, Sponton CH, Araújo MB, Bomfim LH, Queiroz AL, Passos MA, E Sousa TA, Hirabara SM, Martins AR, Sampaio HC, Rodrigues A, Curi R, Carneiro EM, Boschero AC, Silveira LR. Lima TI, et al. Among authors: sponton ch. J Cell Physiol. 2017 May;232(5):958-966. doi: 10.1002/jcp.25645. Epub 2016 Oct 26. J Cell Physiol. 2017. PMID: 27736004 Review.
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