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Drug interactions with phytotherapeutics in oncology.
Haefeli WE, Carls A. Haefeli WE, et al. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):359-77. doi: 10.1517/17425255.2014.873786. Epub 2014 Jan 6. Expert Opin Drug Metab Toxicol. 2014. PMID: 24387348 Review.
Echinacea can induce drug metabolism mediated by CYP3A, but most likely relevant when administered with substances with a narrow therapeutic index or low oral bioavailability. ...
Echinacea can induce drug metabolism mediated by CYP3A, but most likely relevant when administered with substances with a narrow ther …
Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review.
Pariente G, Leibson T, Carls A, Adams-Webber T, Ito S, Koren G. Pariente G, et al. Among authors: carls a. PLoS Med. 2016 Nov 1;13(11):e1002160. doi: 10.1371/journal.pmed.1002160. eCollection 2016 Nov. PLoS Med. 2016. PMID: 27802281 Free PMC article. Review.
Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.
Hohmann N, Reinhard R, Schnaidt S, Witt L, Carls A, Burhenne J, Mikus G, Haefeli WE. Hohmann N, et al. Among authors: carls a. J Antimicrob Chemother. 2016 Aug;71(8):2241-7. doi: 10.1093/jac/dkw125. Epub 2016 May 1. J Antimicrob Chemother. 2016. PMID: 27141088 Clinical Trial.
Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole.
Hohmann N, Kocheise F, Carls A, Burhenne J, Weiss J, Haefeli WE, Mikus G. Hohmann N, et al. Among authors: carls a. Clin Pharmacokinet. 2016 Dec;55(12):1535-1545. doi: 10.1007/s40262-016-0416-1. Clin Pharmacokinet. 2016. PMID: 27236320 Clinical Trial.
St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions.
Hohmann N, Maus A, Carls A, Haefeli WE, Mikus G. Hohmann N, et al. Among authors: carls a. Arch Toxicol. 2016 Apr;90(4):1013-5. doi: 10.1007/s00204-015-1532-7. Epub 2015 May 12. Arch Toxicol. 2016. PMID: 25963330 Clinical Trial.
Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity.
Carls A, Jedamzik J, Witt L, Hohmann N, Burhenne J, Mikus G. Carls A, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1433-40. doi: 10.1111/bcp.12497. Br J Clin Pharmacol. 2014. PMID: 25139487 Free PMC article. Clinical Trial.
Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions.
Geist MJP, Egerer G, Mikus G, Blank A, Hohmann N, Heinz WJ, Carls A. Geist MJP, et al. Among authors: carls a. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):56-61. doi: 10.1111/bcpt.13093. Epub 2018 Aug 2. Basic Clin Pharmacol Toxicol. 2019. PMID: 29989301 Free article. Clinical Trial.
Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans.
Hohmann N, Kocheise F, Carls A, Burhenne J, Haefeli WE, Mikus G. Hohmann N, et al. Among authors: carls a. Br J Clin Pharmacol. 2015 Feb;79(2):278-85. doi: 10.1111/bcp.12502. Br J Clin Pharmacol. 2015. PMID: 25588320 Free PMC article. Clinical Trial.
Substantially increased sildenafil bioavailability after sublingual administration in children with congenital heart disease: two case reports.
Carls A, Winter J, Enderle Y, Burhenne J, Gorenflo M, Haefeli WE. Carls A, et al. J Med Case Rep. 2014 May 30;8:171. doi: 10.1186/1752-1947-8-171. J Med Case Rep. 2014. PMID: 24885923 Free PMC article.
INTRODUCTION: Pulmonary hypertension is a progressive disease of diverse origin with devastating consequences in adults as well as in children. ...Sublingual sildenafil appears to be a promising alternative route of administration in children with poor enteral absor …
INTRODUCTION: Pulmonary hypertension is a progressive disease of diverse origin with devastating consequences in adults as well as in …
Percutaneous instillation of physiological saline solution for the treatment of femoral pseudoaneuryms.
Giurgea GA, Mlekusch I, Hoke M, Carls A, Sabeti-Sandor S, Minar E, Mlekusch W. Giurgea GA, et al. Among authors: carls a. Wien Klin Wochenschr. 2016 Jun;128(11-12):421-5. doi: 10.1007/s00508-016-0979-8. Epub 2016 Mar 15. Wien Klin Wochenschr. 2016. PMID: 26980216 Clinical Trial.
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