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Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection.
Vanhoutte D, van Almen GC, Van Aelst LN, Van Cleemput J, Droogné W, Jin Y, Van de Werf F, Carmeliet P, Vanhaecke J, Papageorgiou AP, Heymans S. Vanhoutte D, et al. Among authors: carmeliet p. Eur Heart J. 2013 Jul;34(25):1930-41. doi: 10.1093/eurheartj/ehs375. Epub 2012 Nov 8. Eur Heart J. 2013. PMID: 23139380 Free PMC article.
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L, Dyspersin GD, Cleutjens JP, Shipley M, Angellilo A, Levi M, Nübe O, Baker A, Keshet E, Lupu F, Herbert JM, Smits JF, Shapiro SD, Baes M, Borgers M, Collen D, Daemen MJ, Carmeliet P. Heymans S, et al. Among authors: carmeliet p. Nat Med. 1999 Oct;5(10):1135-42. doi: 10.1038/13459. Nat Med. 1999. PMID: 10502816
Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart.
Heymans S, Schroen B, Vermeersch P, Milting H, Gao F, Kassner A, Gillijns H, Herijgers P, Flameng W, Carmeliet P, Van de Werf F, Pinto YM, Janssens S. Heymans S, et al. Among authors: carmeliet p. Circulation. 2005 Aug 23;112(8):1136-44. doi: 10.1161/CIRCULATIONAHA.104.516963. Epub 2005 Aug 15. Circulation. 2005. PMID: 16103240
Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis.
Heymans S, Pauschinger M, De Palma A, Kallwellis-Opara A, Rutschow S, Swinnen M, Vanhoutte D, Gao F, Torpai R, Baker AH, Padalko E, Neyts J, Schultheiss HP, Van de Werf F, Carmeliet P, Pinto YM. Heymans S, et al. Among authors: carmeliet p. Circulation. 2006 Aug 8;114(6):565-73. doi: 10.1161/CIRCULATIONAHA.105.591032. Epub 2006 Jul 31. Circulation. 2006. PMID: 16880329
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction.
Vanhoutte D, Schellings MW, Götte M, Swinnen M, Herias V, Wild MK, Vestweber D, Chorianopoulos E, Cortés V, Rigotti A, Stepp MA, Van de Werf F, Carmeliet P, Pinto YM, Heymans S. Vanhoutte D, et al. Among authors: carmeliet p. Circulation. 2007 Jan 30;115(4):475-82. doi: 10.1161/CIRCULATIONAHA.106.644609. Epub 2007 Jan 22. Circulation. 2007. PMID: 17242279 Free article.
Absence of thrombospondin-2 causes age-related dilated cardiomyopathy.
Swinnen M, Vanhoutte D, Van Almen GC, Hamdani N, Schellings MW, D'hooge J, Van der Velden J, Weaver MS, Sage EH, Bornstein P, Verheyen FK, VandenDriessche T, Chuah MK, Westermann D, Paulus WJ, Van de Werf F, Schroen B, Carmeliet P, Pinto YM, Heymans S. Swinnen M, et al. Among authors: carmeliet p. Circulation. 2009 Oct 20;120(16):1585-97. doi: 10.1161/CIRCULATIONAHA.109.863266. Epub 2009 Oct 5. Circulation. 2009. PMID: 19805649 Free article.
770 results