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Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Caruso P, et al. Among authors: carmeliet p. Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26. Circulation. 2017. PMID: 28971999 Free PMC article.
Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.
Storkebaum E, Ruiz de Almodovar C, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Miskiewicz K, Poesen K, Lambrechts D, Janssen GM, Fazzi GE, Verstreken P, Haigh J, Schiffers PM, Rohrer H, Van der Linden A, De Mey JG, Carmeliet P. Storkebaum E, et al. Among authors: carmeliet p. Circulation. 2010 Jul 20;122(3):273-81. doi: 10.1161/CIRCULATIONAHA.109.929364. Epub 2010 Jul 6. Circulation. 2010. PMID: 20606119 Free article.
Role of PFKFB3-driven glycolysis in vessel sprouting.
De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. De Bock K, et al. Among authors: carmeliet p. Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037. Cell. 2013. PMID: 23911327 Free article.
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Schoors S, De Bock K, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, Bifari F, Wang X, Blanco R, Tembuyser B, Cornelissen I, Bouché A, Vinckier S, Diaz-Moralli S, Gerhardt H, Telang S, Cascante M, Chesney J, Dewerchin M, Carmeliet P. Schoors S, et al. Among authors: carmeliet p. Cell Metab. 2014 Jan 7;19(1):37-48. doi: 10.1016/j.cmet.2013.11.008. Epub 2013 Dec 12. Cell Metab. 2014. PMID: 24332967 Free article.
Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.
Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A. Coppiello G, et al. Among authors: carmeliet p. Circulation. 2015 Mar 3;131(9):815-26. doi: 10.1161/CIRCULATIONAHA.114.013721. Epub 2015 Jan 5. Circulation. 2015. PMID: 25561514 Free article.
Metabolic adaptations in diabetic endothelial cells.
de Zeeuw P, Wong BW, Carmeliet P. de Zeeuw P, et al. Among authors: carmeliet p. Circ J. 2015;79(5):934-41. doi: 10.1253/circj.CJ-15-0230. Epub 2015 Mar 17. Circ J. 2015. PMID: 25787231 Free article. Review.
Endothelial cell metabolism in normal and diseased vasculature.
Eelen G, de Zeeuw P, Simons M, Carmeliet P. Eelen G, et al. Among authors: carmeliet p. Circ Res. 2015 Mar 27;116(7):1231-44. doi: 10.1161/CIRCRESAHA.116.302855. Circ Res. 2015. PMID: 25814684 Free PMC article. Review.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P. Schoors S, et al. Among authors: carmeliet p. Nature. 2015 Apr 9;520(7546):192-197. doi: 10.1038/nature14362. Epub 2015 Apr 1. Nature. 2015. PMID: 25830893 Free PMC article.
770 results