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Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice.
Meck WH, Cheng RK, MacDonald CJ, Gainetdinov RR, Caron MG, Cevik MÖ. Meck WH, et al. Neuropharmacology. 2012 Mar;62(3):1221-9. doi: 10.1016/j.neuropharm.2011.01.042. Epub 2011 Feb 4. Neuropharmacology. 2012. PMID: 21296093
MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice.
Powell SB, Lehmann-Masten VD, Paulus MP, Gainetdinov RR, Caron MG, Geyer MA. Powell SB, et al. Psychopharmacology (Berl). 2004 May;173(3-4):310-7. doi: 10.1007/s00213-003-1765-7. Epub 2004 Jan 28. Psychopharmacology (Berl). 2004. PMID: 14747902
METHODS: The effects of MDMA (10, 30 mg/kg) on locomotor activity in DAT (+/+) mice were measured for 90 min in a video tracker system to determine the optimal dose for subsequent studies in DAT (+/+) and (-/-) mice. ...In DAT (-/-) mice, however, MDMA (20 mg/kg) at …
METHODS: The effects of MDMA (10, 30 mg/kg) on locomotor activity in DAT (+/+) mice were measured for 90 min in a video tracker syste …
Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.
Wong P, Chang CC, Marx CE, Caron MG, Wetsel WC, Zhang X. Wong P, et al. PLoS One. 2012;7(12):e51455. doi: 10.1371/journal.pone.0051455. Epub 2012 Dec 11. PLoS One. 2012. PMID: 23240026 Free PMC article.
At 60 mg/kg of pregnenolone, there were no significant differences in locomotor activities and stereotypy between wild-type and DAT KO mice. Similarly, acute treatment of 60 mg/kg of pregnenolone fully rescued PPI deficits of DAT KO mice. Following chronic treatment …
At 60 mg/kg of pregnenolone, there were no significant differences in locomotor activities and stereotypy between wild-type and DAT K …
Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice.
Medvedev IO, Gainetdinov RR, Sotnikova TD, Bohn LM, Caron MG, Dykstra LA. Medvedev IO, et al. Psychopharmacology (Berl). 2005 Jul;180(3):408-13. doi: 10.1007/s00213-005-2173-y. Epub 2005 Feb 18. Psychopharmacology (Berl). 2005. PMID: 15719221
Conditioning consisted of three 30-min sessions with cocaine (2.5, 5.0, 10.0, 20.0, or 40.0 mg/kg) and three 30-min sessions with saline. ...RESULTS: DAT-WT mice revealed CPP over a wide range of cocaine doses (5.0-40 mg/kg), whereas DAT-KO mice revealed CPP over a …
Conditioning consisted of three 30-min sessions with cocaine (2.5, 5.0, 10.0, 20.0, or 40.0 mg/kg) and three 30-min sessions with sal …
The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice.
Barr AM, Lehmann-Masten V, Paulus M, Gainetdinov RR, Caron MG, Geyer MA. Barr AM, et al. Neuropsychopharmacology. 2004 Feb;29(2):221-8. doi: 10.1038/sj.npp.1300343. Neuropsychopharmacology. 2004. PMID: 14603268
Treatment with M100907 (0.3-1.0 mg/kg, but not 0.1 mg/kg) reversed locomotor deficits in DAT KO mice. Similarly, treatment with 1.0 mg/kg M100907 reversed the PPI deficits in DAT KO mice. ...
Treatment with M100907 (0.3-1.0 mg/kg, but not 0.1 mg/kg) reversed locomotor deficits in DAT KO mice. Similarly, treatment wit …
Aberrant responses in social interaction of dopamine transporter knockout mice.
Rodriguiz RM, Chu R, Caron MG, Wetsel WC. Rodriguiz RM, et al. Behav Brain Res. 2004 Jan 5;148(1-2):185-98. doi: 10.1016/s0166-4328(03)00187-6. Behav Brain Res. 2004. PMID: 14684259
Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.
Travis ER, Wang YM, Michael DJ, Caron MG, Wightman RM. Travis ER, et al. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):162-7. doi: 10.1073/pnas.97.1.162. Proc Natl Acad Sci U S A. 2000. PMID: 10618388 Free PMC article.
Genetic animal models: focus on schizophrenia.
Gainetdinov RR, Mohn AR, Caron MG. Gainetdinov RR, et al. Trends Neurosci. 2001 Sep;24(9):527-33. doi: 10.1016/s0166-2236(00)01886-5. Trends Neurosci. 2001. PMID: 11506886 Review.
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