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Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.
Kang-Pettinger T, Walker K, Brown R, Cowan R, Wright H, Baravalle R, Waters LC, Muskett FW, Bowler MW, Sawmynaden K, Coombs PJ, Carr MD, Hall G. Kang-Pettinger T, et al. Among authors: carr md. J Biol Chem. 2023 Jan;299(1):102769. doi: 10.1016/j.jbc.2022.102769. Epub 2022 Dec 5. J Biol Chem. 2023. PMID: 36470427 Free PMC article.
Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
Hall G, Cullen E, Sawmynaden K, Arnold J, Fox S, Cowan R, Muskett FW, Matthews D, Merritt A, Kettleborough C, Cruikshank W, Taylor D, Bayliss R, Carr MD. Hall G, et al. Among authors: carr md. J Biol Chem. 2016 Aug 5;291(32):16840-8. doi: 10.1074/jbc.M115.709303. Epub 2016 May 26. J Biol Chem. 2016. PMID: 27231345 Free PMC article.
Structural diversity in p160/CREB-binding protein coactivator complexes.
Waters L, Yue B, Veverka V, Renshaw P, Bramham J, Matsuda S, Frenkiel T, Kelly G, Muskett F, Carr M, Heery DM. Waters L, et al. J Biol Chem. 2006 May 26;281(21):14787-95. doi: 10.1074/jbc.M600237200. Epub 2006 Mar 15. J Biol Chem. 2006. PMID: 16540468 Free article.
Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
Waters LC, Strong SL, Ferlemann E, Oka O, Muskett FW, Veverka V, Banerjee S, Schmedt T, Henry AJ, Klempnauer KH, Carr MD. Waters LC, et al. Among authors: carr md. J Biol Chem. 2011 May 13;286(19):17270-80. doi: 10.1074/jbc.M110.166157. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454508 Free PMC article.
Conformational heterogeneity in antibody-protein antigen recognition: implications for high affinity protein complex formation.
Addis PW, Hall CJ, Bruton S, Veverka V, Wilkinson IC, Muskett FW, Renshaw PS, Prosser CE, Carrington B, Lawson ADG, Griffin R, Taylor RJ, Waters LC, Henry AJ, Carr MD. Addis PW, et al. Among authors: carr md. J Biol Chem. 2014 Mar 7;289(10):7200-7210. doi: 10.1074/jbc.M113.492215. Epub 2014 Jan 16. J Biol Chem. 2014. PMID: 24436329 Free PMC article.
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
Patel S, Barkell AM, Gupta D, Strong SL, Bruton S, Muskett FW, Addis PW, Renshaw PS, Slocombe PM, Doyle C, Clargo A, Taylor RJ, Prosser CE, Henry AJ, Robinson MK, Waters LC, Holdsworth G, Carr MD. Patel S, et al. Among authors: carr md. J Biol Chem. 2018 Aug 3;293(31):12149-12166. doi: 10.1074/jbc.RA118.002918. Epub 2018 Jun 20. J Biol Chem. 2018. PMID: 29925589 Free PMC article.
Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
Schairer R, Hall G, Zhang M, Cowan R, Baravalle R, Muskett FW, Coombs PJ, Mpamhanga C, Hale LR, Saxty B, Iwaszkiewicz J, Décaillet C, Perroud M, Carr MD, Thome M. Schairer R, et al. Among authors: carr md. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3093-3102. doi: 10.1073/pnas.1912681117. Epub 2020 Jan 24. Proc Natl Acad Sci U S A. 2020. PMID: 31980531 Free PMC article.
73 results