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Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.
Secci D, Bolasco A, Carradori S, D'Ascenzio M, Nescatelli R, Yáñez M. Secci D, et al. Eur J Med Chem. 2012 Dec;58:405-17. doi: 10.1016/j.ejmech.2012.10.032. Epub 2012 Oct 26. Eur J Med Chem. 2012. PMID: 23153812
Synthesis and in vitro selective anti-Helicobacter pylori activity of N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.
Chimenti F, Bizzarri B, Bolasco A, Secci D, Chimenti P, Carradori S, Granese A, Rivanera D, Lilli D, Scaltrito MM, Brenciaglia MI. Chimenti F, et al. Eur J Med Chem. 2006 Feb;41(2):208-12. doi: 10.1016/j.ejmech.2005.11.001. Epub 2006 Jan 10. Eur J Med Chem. 2006. PMID: 16377035
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of N,N'-bis[2-oxo-2H-benzopyran]-3-carboxamides.
Chimenti F, Secci D, Bolasco A, Chimenti P, Granese A, Carradori S, Befani O, Turini P, Alcaro S, Ortuso F. Chimenti F, et al. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4135-40. doi: 10.1016/j.bmcl.2006.04.026. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16759860
A novel class of selective anti-Helicobacter pylori agents 2-oxo-2H-chromene-3-carboxamide derivatives.
Chimenti F, Bizzarri B, Bolasco A, Secci D, Chimenti P, Carradori S, Granese A, Rivanera D, Lilli D, Zicari A, Scaltrito MM, Sisto F. Chimenti F, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3065-71. doi: 10.1016/j.bmcl.2007.03.050. Epub 2007 Mar 19. Bioorg Med Chem Lett. 2007. PMID: 17395462
Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.
Chimenti F, Bizzarri B, Maccioni E, Secci D, Bolasco A, Fioravanti R, Chimenti P, Granese A, Carradori S, Rivanera D, Lilli D, Zicari A, Distinto S. Chimenti F, et al. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4635-40. doi: 10.1016/j.bmcl.2007.05.078. Epub 2007 May 27. Bioorg Med Chem Lett. 2007. PMID: 17560783
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.
Chimenti F, Maccioni E, Secci D, Bolasco A, Chimenti P, Granese A, Carradori S, Alcaro S, Ortuso F, Yáñez M, Orallo F, Cirilli R, Ferretti R, La Torre F. Chimenti F, et al. J Med Chem. 2008 Aug 28;51(16):4874-80. doi: 10.1021/jm800132g. Epub 2008 Jul 31. J Med Chem. 2008. PMID: 18666768
The target compounds, which present a stereogenic center on the cyclohexane ring, were obtained as pure (R) and (S) enantiomers by enantioselective HPLC. ...
The target compounds, which present a stereogenic center on the cyclohexane ring, were obtained as pure (R) and (S) enantiomers by en …
A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone.
Chimenti F, Bizzarri B, Maccioni E, Secci D, Bolasco A, Chimenti P, Fioravanti R, Granese A, Carradori S, Tosi F, Ballario P, Vernarecci S, Filetici P. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6. doi: 10.1021/jm800885d. J Med Chem. 2009. PMID: 19099397
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
Chimenti F, Secci D, Bolasco A, Chimenti P, Bizzarri B, Granese A, Carradori S, Yáñez M, Orallo F, Ortuso F, Alcaro S. Chimenti F, et al. J Med Chem. 2009 Apr 9;52(7):1935-42. doi: 10.1021/jm801496u. J Med Chem. 2009. PMID: 19267475
Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro.
Chimenti F, Bizzarri B, Bolasco A, Secci D, Chimenti P, Carradori S, Granese A, Rivanera D, Frishberg N, Bordón C, Jones-Brando L. Chimenti F, et al. J Med Chem. 2009 Aug 13;52(15):4574-7. doi: 10.1021/jm9005862. J Med Chem. 2009. PMID: 19618935
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.
Chimenti F, Carradori S, Secci D, Bolasco A, Bizzarri B, Chimenti P, Granese A, Yáñez M, Orallo F. Chimenti F, et al. Eur J Med Chem. 2010 Feb;45(2):800-4. doi: 10.1016/j.ejmech.2009.11.003. Epub 2009 Nov 6. Eur J Med Chem. 2010. PMID: 19926363
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