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Alpha1-antitrypsin deficiency--a model for conformational diseases.
Carrell RW, Lomas DA. Carrell RW, et al. N Engl J Med. 2002 Jan 3;346(1):45-53. doi: 10.1056/NEJMra010772. N Engl J Med. 2002. PMID: 11778003 Review. No abstract available.
What can Drosophila tell us about serpins, thrombosis and dementia?
Carrell R, Corral J. Carrell R, et al. Bioessays. 2004 Jan;26(1):1-5. doi: 10.1002/bies.10407. Bioessays. 2004. PMID: 14696034 Review.
Serpin polymerization is prevented by a hydrogen bond network that is centered on his-334 and stabilized by glycerol.
Zhou A, Stein PE, Huntington JA, Carrell RW. Zhou A, et al. Among authors: carrell rw. J Biol Chem. 2003 Apr 25;278(17):15116-22. doi: 10.1074/jbc.M211663200. Epub 2003 Feb 10. J Biol Chem. 2003. PMID: 12578831
Serpinopathies and the conformational dementias.
Lomas DA, Carrell RW. Lomas DA, et al. Among authors: carrell rw. Nat Rev Genet. 2002 Oct;3(10):759-68. doi: 10.1038/nrg907. Nat Rev Genet. 2002. PMID: 12360234 Review.
How serpins transport hormones and regulate their release.
Carrell RW, Read RJ. Carrell RW, et al. Semin Cell Dev Biol. 2017 Feb;62:133-141. doi: 10.1016/j.semcdb.2016.12.007. Epub 2016 Dec 24. Semin Cell Dev Biol. 2017. PMID: 28027946 Review.
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X.
Wei Z, Yan Y, Carrell RW, Zhou A. Wei Z, et al. Among authors: carrell rw. Blood. 2009 Oct 22;114(17):3662-7. doi: 10.1182/blood-2009-04-210021. Epub 2009 Jun 15. Blood. 2009. PMID: 19528533 Free PMC article.
Dimers initiate and propagate serine protease inhibitor polymerisation.
Zhou A, Carrell RW. Zhou A, et al. Among authors: carrell rw. J Mol Biol. 2008 Jan 4;375(1):36-42. doi: 10.1016/j.jmb.2007.10.055. Epub 2007 Oct 25. J Mol Biol. 2008. PMID: 18005992
How serpins change their fold for better and for worse.
Carrell RW, Huntington JA. Carrell RW, et al. Biochem Soc Symp. 2003;(70):163-78. doi: 10.1042/bss0700163. Biochem Soc Symp. 2003. PMID: 14587291 Review.
6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
Mahadeva R, Dafforn TR, Carrell RW, Lomas DA. Mahadeva R, et al. Among authors: carrell rw. J Biol Chem. 2002 Mar 1;277(9):6771-4. doi: 10.1074/jbc.C100722200. Epub 2001 Dec 28. J Biol Chem. 2002. PMID: 11773044
Molecular Mechanism of Z α1-Antitrypsin Deficiency.
Huang X, Zheng Y, Zhang F, Wei Z, Wang Y, Carrell RW, Read RJ, Chen GQ, Zhou A. Huang X, et al. Among authors: carrell rw. J Biol Chem. 2016 Jul 22;291(30):15674-86. doi: 10.1074/jbc.M116.727826. Epub 2016 May 31. J Biol Chem. 2016. PMID: 27246852 Free PMC article.
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