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Inherited variability of the mitochondrial genome and successful aging in humans.
de Benedictis G, Carrieri G, Varcasia O, Bonafè M, Franceschi C. de Benedictis G, et al. Ann N Y Acad Sci. 2000 Jun;908:208-18. doi: 10.1111/j.1749-6632.2000.tb06648.x. Ann N Y Acad Sci. 2000. PMID: 10911960 Review.
An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.
Bonafè M, Barbi C, Olivieri F, Yashin A, Andreev KF, Vaupel JW, De Benedictis G, Rose G, Carrieri G, Jazwinski SM, Franceschi C. Bonafè M, et al. Gene. 2002 Mar 6;286(1):121-6. doi: 10.1016/s0378-1119(01)00812-5. Gene. 2002. PMID: 11943467
In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafè M, Giovagnetti S, Stecconi R, Cardelli M, Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C, Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S, Franceschi C. Olivieri F, et al. Mech Ageing Dev. 2003 Apr;124(4):549-53. doi: 10.1016/s0047-6374(03)00035-6. Mech Ageing Dev. 2003. PMID: 12714266
The subjects were genotypized for the C to G transition at nucleotide -174 of IL-6 gene promoter (-174 C/G) and were classified as C allele carriers (C+) and non-carriers (C-). We found that: (i) the interindividual difference in in vitro IL-6 production was wider i …
The subjects were genotypized for the C to G transition at nucleotide -174 of IL-6 gene promoter (-174 C/G) and were classifie …
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.
Carrieri G, Marzi E, Olivieri F, Marchegiani F, Cavallone L, Cardelli M, Giovagnetti S, Stecconi R, Molendini C, Trapassi C, De Benedictis G, Kletsas D, Franceschi C. Carrieri G, et al. Aging Cell. 2004 Dec;3(6):443-8. doi: 10.1111/j.1474-9728.2004.00129.x. Aging Cell. 2004. PMID: 15569360
Two polymorphisms, G/A -800 and C/T -509, located in the 5' region, and two missense polymorphisms, T/C 869 and G/C 915 which change (Leu > Pro)10 and (Arg > Pro)25, respectively, located in the signal peptide, were analysed in 419 subjects from Northern and C …
Two polymorphisms, G/A -800 and C/T -509, located in the 5' region, and two missense polymorphisms, T/C 869 and G/C 915 which …
Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians.
Rose G, Passarino G, Carrieri G, Altomare K, Greco V, Bertolini S, Bonafè M, Franceschi C, De Benedictis G. Rose G, et al. Eur J Hum Genet. 2001 Sep;9(9):701-7. doi: 10.1038/sj.ejhg.5200703. Eur J Hum Genet. 2001. PMID: 11571560
Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease.
Carrieri G, Bonafè M, De Luca M, Rose G, Varcasia O, Bruni A, Maletta R, Nacmias B, Sorbi S, Corsonello F, Feraco E, Andreev KF, Yashin AI, Franceschi C, De Benedictis G. Carrieri G, et al. Hum Genet. 2001 Mar;108(3):194-8. doi: 10.1007/s004390100463. Hum Genet. 2001. PMID: 11354629
Does a retrograde response in human aging and longevity exist?
De Benedictis G, Carrieri G, Garasto S, Rose G, Varcasia O, Bonafè M, Franceschi C, Jazwinski SM. De Benedictis G, et al. Exp Gerontol. 2000 Sep;35(6-7):795-801. doi: 10.1016/s0531-5565(00)00169-8. Exp Gerontol. 2000. PMID: 11053670
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.
De Benedictis G, Rose G, Carrieri G, De Luca M, Falcone E, Passarino G, Bonafe M, Monti D, Baggio G, Bertolini S, Mari D, Mattace R, Franceschi C. De Benedictis G, et al. FASEB J. 1999 Sep;13(12):1532-6. doi: 10.1096/fasebj.13.12.1532. FASEB J. 1999. PMID: 10463944
Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Cavalcanti S, Corsonello F, Feraco E, Baggio G, Bertolini S, Mari D, Mattace R, Yashin AI, Bonafè M, Franceschi C. De Benedictis G, et al. Eur J Hum Genet. 1998 Nov-Dec;6(6):534-41. doi: 10.1038/sj.ejhg.5200222. Eur J Hum Genet. 1998. PMID: 9887369
Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts.
De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Yashin AI, Bonafè M, Franceschi C. De Benedictis G, et al. Ann Hum Genet. 1998 Mar;62(Pt 2):115-22. doi: 10.1046/j.1469-1809.1998.6220115.x. Ann Hum Genet. 1998. PMID: 9759473
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