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Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist.
Barbier AJ, Berridge C, Dugovic C, Laposky AD, Wilson SJ, Boggs J, Aluisio L, Lord B, Mazur C, Pudiak CM, Langlois X, Xiao W, Apodaca R, Carruthers NI, Lovenberg TW. Barbier AJ, et al. Among authors: carruthers ni. Br J Pharmacol. 2004 Nov;143(5):649-61. doi: 10.1038/sj.bjp.0705964. Epub 2004 Oct 4. Br J Pharmacol. 2004. PMID: 15466448 Free PMC article.
Histamine H3 receptor antagonists: from target identification to drug leads.
Bonaventure P, Letavic M, Dugovic C, Wilson S, Aluisio L, Pudiak C, Lord B, Mazur C, Kamme F, Nishino S, Carruthers N, Lovenberg T. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96. doi: 10.1016/j.bcp.2006.10.031. Epub 2006 Nov 3. Biochem Pharmacol. 2007. PMID: 17129577
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
Gelin CF, Stenne B, Coate H, Hiscox A, Soyode-Johnson A, Wall JL, Lord B, Schoellerman J, Coe KJ, Wang K, Alcázar J, Chrovian CC, Dvorak CA, Carruthers NI, Koudriakova T, Balana B, Letavic MA. Gelin CF, et al. Among authors: carruthers ni. J Med Chem. 2023 Feb 23;66(4):2877-2892. doi: 10.1021/acs.jmedchem.2c01916. Epub 2023 Feb 9. J Med Chem. 2023. PMID: 36757100
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate.
Dvorak CA, Rudolph DA, Nepomuceno D, Dvorak L, Lord B, Fraser I, Bonaventure P, Lovenberg T, Carruthers NI. Dvorak CA, et al. Among authors: carruthers ni. Bioorg Med Chem Lett. 2021 Jan 1;31:127669. doi: 10.1016/j.bmcl.2020.127669. Epub 2020 Nov 7. Bioorg Med Chem Lett. 2021. PMID: 33171218
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
Préville C, Bonaventure P, Koudriakova T, Lord B, Nepomuceno D, Rizzolio M, Mani N, Coe KJ, Ndifor A, Dugovic C, Dvorak CA, Coate H, Pippel DJ, Fitzgerald A, Allison B, Lovenberg TW, Carruthers NI, Shireman BT. Préville C, et al. Among authors: carruthers ni. ACS Med Chem Lett. 2020 Apr 27;11(10):2002-2009. doi: 10.1021/acsmedchemlett.0c00085. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062185 Free PMC article.
Copper-mediated synthesis of drug-like bicyclopentanes.
Zhang X, Smith RT, Le C, McCarver SJ, Shireman BT, Carruthers NI, MacMillan DWC. Zhang X, et al. Among authors: carruthers ni. Nature. 2020 Apr;580(7802):220-226. doi: 10.1038/s41586-020-2060-z. Epub 2020 Feb 17. Nature. 2020. PMID: 32066140 Free PMC article.
Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.
Savall BM, Wu D, Swanson DM, Seierstad M, Wu N, Vives Martinez J, García Olmos B, Lord B, Coe K, Koudriakova T, Lovenberg TW, Carruthers NI, Maher MP, Ameriks MK. Savall BM, et al. Among authors: carruthers ni. ACS Med Chem Lett. 2018 Dec 26;10(3):267-272. doi: 10.1021/acsmedchemlett.8b00599. eCollection 2019 Mar 14. ACS Med Chem Lett. 2018. PMID: 30891124 Free PMC article.
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
Chrovian CC, Soyode-Johnson A, Wall JL, Rech JC, Schoellerman J, Lord B, Coe KJ, Carruthers NI, Nguyen L, Jiang X, Koudriakova T, Balana B, Letavic MA. Chrovian CC, et al. Among authors: carruthers ni. ACS Med Chem Lett. 2019 Jan 10;10(3):261-266. doi: 10.1021/acsmedchemlett.8b00542. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891123 Free PMC article.
84 results