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The role of microglia in human disease: therapeutic tool or target?
Cartier N, Lewis CA, Zhang R, Rossi FM. Cartier N, et al. Acta Neuropathol. 2014 Sep;128(3):363-80. doi: 10.1007/s00401-014-1330-y. Epub 2014 Aug 9. Acta Neuropathol. 2014. PMID: 25107477 Free PMC article. Review.
Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future.
Piguet F, Alves S, Cartier N. Piguet F, et al. Among authors: cartier n. Hum Gene Ther. 2017 Nov;28(11):988-1003. doi: 10.1089/hum.2017.160. Hum Gene Ther. 2017. PMID: 29035118 Review.
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.
Cartier N, Hacein-Bey-Abina S, Bartholomae CC, Veres G, Schmidt M, Kutschera I, Vidaud M, Abel U, Dal-Cortivo L, Caccavelli L, Mahlaoui N, Kiermer V, Mittelstaedt D, Bellesme C, Lahlou N, Lefrère F, Blanche S, Audit M, Payen E, Leboulch P, l'Homme B, Bougnères P, Von Kalle C, Fischer A, Cavazzana-Calvo M, Aubourg P. Cartier N, et al. Science. 2009 Nov 6;326(5954):818-23. doi: 10.1126/science.1171242. Science. 2009. PMID: 19892975
Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein.
Asheuer M, Pflumio F, Benhamida S, Dubart-Kupperschmitt A, Fouquet F, Imai Y, Aubourg P, Cartier N. Asheuer M, et al. Among authors: cartier n. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3557-62. doi: 10.1073/pnas.0306431101. Epub 2004 Feb 27. Proc Natl Acad Sci U S A. 2004. PMID: 14990803 Free PMC article.
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.
Fol R, Braudeau J, Ludewig S, Abel T, Weyer SW, Roederer JP, Brod F, Audrain M, Bemelmans AP, Buchholz CJ, Korte M, Cartier N, Müller UC. Fol R, et al. Among authors: cartier n. Acta Neuropathol. 2016 Feb;131(2):247-266. doi: 10.1007/s00401-015-1498-9. Epub 2015 Nov 4. Acta Neuropathol. 2016. PMID: 26538149
Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus.
Chali F, Djelti F, Eugene E, Valderrama M, Marquer C, Aubourg P, Duykaerts C, Miles R, Cartier N, Navarro V. Chali F, et al. Among authors: cartier n. Eur J Neurosci. 2015 May;41(10):1345-55. doi: 10.1111/ejn.12911. Epub 2015 May 12. Eur J Neurosci. 2015. PMID: 25847620 Free PMC article.
Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia.
Nóbrega C, Mendonça L, Marcelo A, Lamazière A, Tomé S, Despres G, Matos CA, Mechmet F, Langui D, den Dunnen W, de Almeida LP, Cartier N, Alves S. Nóbrega C, et al. Among authors: cartier n. Acta Neuropathol. 2019 Nov;138(5):837-858. doi: 10.1007/s00401-019-02019-7. Epub 2019 Jun 14. Acta Neuropathol. 2019. PMID: 31197505
Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.
Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Souchet B, et al. Among authors: cartier n. Acta Neuropathol Commun. 2019 Mar 18;7(1):46. doi: 10.1186/s40478-019-0678-6. Acta Neuropathol Commun. 2019. PMID: 30885273 Free PMC article.
Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.
Hocquemiller M, Giersch L, Audrain M, Parker S, Cartier N. Hocquemiller M, et al. Among authors: cartier n. Hum Gene Ther. 2016 Jul;27(7):478-96. doi: 10.1089/hum.2016.087. Hum Gene Ther. 2016. PMID: 27267688 Free PMC article. Review.
Current and emerging avenues for Alzheimer's disease drug targets.
Loera-Valencia R, Cedazo-Minguez A, Kenigsberg PA, Page G, Duarte AI, Giusti P, Zusso M, Robert P, Frisoni GB, Cattaneo A, Zille M, Boltze J, Cartier N, Buee L, Johansson G, Winblad B. Loera-Valencia R, et al. Among authors: cartier n. J Intern Med. 2019 Oct;286(4):398-437. doi: 10.1111/joim.12959. Epub 2019 Aug 29. J Intern Med. 2019. PMID: 31286586 Free article. Review.
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