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Toxicity of amphetamines: an update.
Carvalho M, Carmo H, Costa VM, Capela JP, Pontes H, Remião F, Carvalho F, Bastos Mde L. Carvalho M, et al. Among authors: Carvalho F. Arch Toxicol. 2012 Aug;86(8):1167-231. doi: 10.1007/s00204-012-0815-5. Epub 2012 Mar 6. Arch Toxicol. 2012. PMID: 22392347 Review.
Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature.
Carvalho M, Carvalho F, Remião F, de Lourdes Pereira M, Pires-das-Neves R, de Lourdes Bastos M. Carvalho M, et al. Among authors: Carvalho F. Arch Toxicol. 2002 Apr;76(3):166-72. doi: 10.1007/s00204-002-0324-z. Epub 2002 Mar 1. Arch Toxicol. 2002. PMID: 11967622
Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells.
Carvalho M, Hawksworth G, Milhazes N, Borges F, Monks TJ, Fernandes E, Carvalho F, Bastos ML. Carvalho M, et al. Among authors: Carvalho F. Arch Toxicol. 2002 Oct;76(10):581-8. doi: 10.1007/s00204-002-0381-3. Epub 2002 Aug 1. Arch Toxicol. 2002. PMID: 12373454
MDMA and MDA were not found to be toxic to either rat or human PTCs at any concentration tested (100-800 micro M). In contrast, 800 micro M alpha-MeDA caused 60% and 40% cell death in rat and human PTCs, respectively. ...Thus, exposure of rat and human PTC monolayers to 400 micro M 5-(glutathion- S-yl)-alpha-MeDA caused approximately 80% and 70% cell death, respectively. 5-(Glutathion- S-yl)-alpha-MeDA (400 micro M) was more toxic than 2,5- bis(glutathion- S-yl)-alpha-MeDA to rat renal PTCs but equally potent in human renal PTCs. ...
MDMA and MDA were not found to be toxic to either rat or human PTCs at any concentration tested (100-800 micro M). In contrast, 800 m …
Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes.
Fernandes E, Carvalho M, Carvalho F, Silva AM, Santos CM, Pinto DC, Cavaleiro JA, de Lourdes Bastos M. Fernandes E, et al. Among authors: Carvalho M, Carvalho F. Arch Toxicol. 2003 Sep;77(9):500-5. doi: 10.1007/s00204-003-0480-9. Epub 2003 Jul 23. Arch Toxicol. 2003. PMID: 12879211
Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates.
Carvalho M, Milhazes N, Remião F, Borges F, Fernandes E, Amado F, Monks TJ, Carvalho F, Bastos ML. Carvalho M, et al. Among authors: Carvalho F. Arch Toxicol. 2004 Jan;78(1):16-24. doi: 10.1007/s00204-003-0510-7. Epub 2003 Oct 28. Arch Toxicol. 2004. PMID: 14586543
Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro.
Carvalho M, Remião F, Milhazes N, Borges F, Fernandes E, Monteiro Mdo C, Gonçalves MJ, Seabra V, Amado F, Carvalho F, Bastos ML. Carvalho M, et al. Among authors: Carvalho F. Chem Res Toxicol. 2004 May;17(5):623-32. doi: 10.1021/tx049960f. Chem Res Toxicol. 2004. PMID: 15144219
Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: formation of adrenochrome, quinoproteins, and GSH adduct.
Costa VM, Silva R, Ferreira LM, Branco PS, Carvalho F, Bastos ML, Carvalho RA, Carvalho M, Remião F. Costa VM, et al. Among authors: Carvalho F, Carvalho RA, Carvalho M. Chem Res Toxicol. 2007 Aug;20(8):1183-91. doi: 10.1021/tx7000916. Epub 2007 Jul 13. Chem Res Toxicol. 2007. PMID: 17630707
Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes.
Costa VM, Silva R, Ferreira R, Amado F, Carvalho F, de Lourdes Bastos M, Carvalho RA, Carvalho M, Remião F. Costa VM, et al. Among authors: Carvalho F, Carvalho RA, Carvalho M. Toxicology. 2009 Mar 4;257(1-2):70-9. doi: 10.1016/j.tox.2008.12.010. Epub 2008 Dec 24. Toxicology. 2009. PMID: 19135123
Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes.
Costa VM, Silva R, Tavares LC, Vitorino R, Amado F, Carvalho F, Bastos Mde L, Carvalho M, Carvalho RA, Remião F. Costa VM, et al. Among authors: Carvalho F, Carvalho M, Carvalho RA. Toxicology. 2009 Jun 16;260(1-3):84-96. doi: 10.1016/j.tox.2009.03.012. Epub 2009 Mar 25. Toxicology. 2009. PMID: 19464573
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