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Scanning electron microscopy of encapsulated and non-encapsulated Cryptococcus neoformans and the effect of glucose on capsular polysaccharide release.
Cleare W, Casadevall A. Cleare W, et al. Med Mycol. 1999 Aug;37(4):235-43. Med Mycol. 1999. PMID: 10421858
Examination of the encapsulated C. neoformans strains 24067 and 34873 by scanning electron microscopy (SEM) revealed globular cells covered with a loose fibrillar network which was most prominent during the early stationary phase. ...In contrast, SEM of strain 52817, a
Examination of the encapsulated C. neoformans strains 24067 and 34873 by scanning electron microscopy (SEM) revealed globular cells covered …
Extensive allelic variation in Cryptococcus neoformans.
Casadevall A, Freundlich LF, Marsh L, Scharff MD. Casadevall A, et al. J Clin Microbiol. 1992 May;30(5):1080-4. doi: 10.1128/JCM.30.5.1080-1084.1992. J Clin Microbiol. 1992. PMID: 1349897 Free PMC article.
Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans.
Pettoello-Mantovani M, Casadevall A, Kollmann TR, Rubinstein A, Goldstein H. Pettoello-Mantovani M, et al. Lancet. 1992 Jan 4;339(8784):21-3. doi: 10.1016/0140-6736(92)90142-p. Lancet. 1992. PMID: 1370335
Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptococcal capsular polysaccharide may enhance HIV-1 infection. ...Our findings suggest a new pathogenic role for the capsular polysacchar …
Patients with AIDS who become infected with Cryptococcus neoformans have a poor prognosis. We speculated that the presence of cryptoc …
Protective murine monoclonal antibodies to Cryptococcus neoformans.
Mukherjee J, Scharff MD, Casadevall A. Mukherjee J, et al. Infect Immun. 1992 Nov;60(11):4534-41. doi: 10.1128/IAI.60.11.4534-4541.1992. Infect Immun. 1992. PMID: 1398966 Free PMC article.
The protection model used A/J and BALB/c mice infected intraperitoneally with 10(8) cryptococci. The MAbs were administered either immediately preceding or, in one experiment, 24 to 48 h prior to infection. ...Three IgM MAbs, each of which recognized a distinct epit …
The protection model used A/J and BALB/c mice infected intraperitoneally with 10(8) cryptococci. The MAbs were administered either im …
Monoclonal antibody based ELISAs for cryptococcal polysaccharide.
Casadevall A, Mukherjee J, Scharff MD. Casadevall A, et al. J Immunol Methods. 1992 Sep 18;154(1):27-35. doi: 10.1016/0022-1759(92)90209-c. J Immunol Methods. 1992. PMID: 1401941
Mouse monoclonal antibody (MAb)-based enzyme-linked immunosorbent assays (ELISAs) have been developed to detect Cryptococcus neoformans capsular polysaccharide from the four serotypes A, B, C and D. ...The presence of polysaccharide is detected using MAbs of a diffe …
Mouse monoclonal antibody (MAb)-based enzyme-linked immunosorbent assays (ELISAs) have been developed to detect Cryptococcus neoformans caps …
Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection.
Casadevall A, Mukherjee J, Devi SJ, Schneerson R, Robbins JB, Scharff MD. Casadevall A, et al. J Infect Dis. 1992 Jun;165(6):1086-93. doi: 10.1093/infdis/165.6.1086. J Infect Dis. 1992. PMID: 1583327
The antibody responses of BALB/c mice to serotype A Cryptococcus neoformans capsular polysaccharide (CNPS) were compared after cryptococcal infection and immunization with a serotype A glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT). ...For some MAbs, d …
The antibody responses of BALB/c mice to serotype A Cryptococcus neoformans capsular polysaccharide (CNPS) were compared after crypto …
The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies.
Casadevall A, Scharff MD. Casadevall A, et al. J Exp Med. 1991 Jul 1;174(1):151-60. doi: 10.1084/jem.174.1.151. J Exp Med. 1991. PMID: 1676047 Free PMC article.
Cryptococcus neoformans is a ubiquitous fungus that can cause serious infections in humans. The fungus has a polysaccharide (C. neoformans capsular polysaccharide; CNPS) capsule that contributes to its pathogenicity and can elicit an antibody response. Nevertheless, …
Cryptococcus neoformans is a ubiquitous fungus that can cause serious infections in humans. The fungus has a polysaccharide (C …
Monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan enhance fluconazole efficacy.
Mukherjee J, Feldmesser M, Scharff MD, Casadevall A. Mukherjee J, et al. Antimicrob Agents Chemother. 1995 Jul;39(7):1398-405. doi: 10.1128/aac.39.7.1398. Antimicrob Agents Chemother. 1995. PMID: 7492075 Free PMC article.
Fluconazole (FLU) is a triazole antibiotic which is effective against C. neoformans. The efficacy of MAb 2H1 in combination with FLU was studied in vitro with the murine macrophage-like cell line J7741.16 and in vivo in mice infected intravenously. ...For the in vivo exper …
Fluconazole (FLU) is a triazole antibiotic which is effective against C. neoformans. The efficacy of MAb 2H1 in combination with FLU …
Human microglia mediate anti-Cryptococcus neoformans activity in the presence of specific antibody.
Lee SC, Kress Y, Dickson DW, Casadevall A. Lee SC, et al. J Neuroimmunol. 1995 Oct;62(1):43-52. doi: 10.1016/0165-5728(95)00097-l. J Neuroimmunol. 1995. PMID: 7499491
Addition of the murine monoclonal antibody (mAb) 2H1 (IgG1, kappa) to the capsular glucuronoxylomannan (GXM) produced a dose-dependent enhancement of C. neoformans phagocytosis by microglia. ...Enhancement of microglial activity in vivo by opsonins may be a useful t …
Addition of the murine monoclonal antibody (mAb) 2H1 (IgG1, kappa) to the capsular glucuronoxylomannan (GXM) produced a dose-dependen …
The 16S-like, 5.8S and 23S-like rRNAs of the two varieties of Cryptococcus neoformans: sequence, secondary structure, phylogenetic analysis and restriction fragment polymorphisms.
Fan M, Currie BP, Gutell RR, Ragan MA, Casadevall A. Fan M, et al. J Med Vet Mycol. 1994;32(3):163-80. doi: 10.1080/02681219480000231. J Med Vet Mycol. 1994. PMID: 7525916
The rRNA locus has the typical eukaryote organization of 16S-5.8S-23S with the 16S-like and 5.8S rRNA genes separated by a 124-nucleotide spacer and the 5.8S and 23S-like rRNA genes separated by a 187-nucleotide spacer in each strain. The C. neoformans var. neoforma …
The rRNA locus has the typical eukaryote organization of 16S-5.8S-23S with the 16S-like and 5.8S rRNA genes separated by a 124-nucleo …
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