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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.
Al-Hamashi AA, Koranne R, Dlamini S, Alqahtani A, Karaj E, Rashid MS, Knoff JR, Dunworth M, Pflum MKH, Casero RA Jr, Perera L, Taylor WR, Tillekeratne LMV. Al-Hamashi AA, et al. Among authors: casero ra jr. Bioorg Chem. 2021 Aug 30;116:105297. doi: 10.1016/j.bioorg.2021.105297. Online ahead of print. Bioorg Chem. 2021. PMID: 34509798
A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.
Murray Stewart T, Von Hoff D, Fitzgerald M, Marton LJ, Becerra CHR, Boyd TE, Conkling PR, Garbo LE, Jotte RM, Richards DA, Smith DA, Stephenson JJ Jr, Vogelzang NJ, Wu HH, Casero RA Jr. Murray Stewart T, et al. Among authors: casero ra jr. Cancer Chemother Pharmacol. 2021 Jan;87(1):135-144. doi: 10.1007/s00280-020-04201-1. Epub 2020 Nov 19. Cancer Chemother Pharmacol. 2021. PMID: 33215270 Clinical Trial.
Identification of a Novel Substrate-Derived Spermine Oxidase Inhibitor.
Dunston TT, Khomutov MA, Gabelli SB, Stewart TM, Foley JR, Kochetkov SN, Khomutov AR, Casero RA Jr. Dunston TT, et al. Among authors: casero ra jr. Acta Naturae. 2020 Jul-Sep;12(3):140-144. doi: 10.32607/actanaturae.10992. Acta Naturae. 2020. PMID: 33173604 Free PMC article.
Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
Zahedi K, Brooks M, Barone S, Rahmati N, Murray Stewart T, Dunworth M, Destefano-Shields C, Dasgupta N, Davidson S, Lindquist DM, Fuller CE, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M. Zahedi K, et al. Among authors: casero ra jr. J Neuroinflammation. 2020 Oct 14;17(1):301. doi: 10.1186/s12974-020-01955-6. J Neuroinflammation. 2020. PMID: 33054763 Free PMC article.
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