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Filters applied: . Clear all The following term was not found in PubMed: inflammaso
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM. Kayagaki N, et al. Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16. Nature. 2015. PMID: 26375259
How caspase-11 executes these downstream signalling events is largely unknown. Here we show that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation. ...Mechanistically, caspase-11 c
How caspase-11 executes these downstream signalling events is largely unknown. Here we show that gasdermin D is …
Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome.
Ross C, Chan AH, Von Pein J, Boucher D, Schroder K. Ross C, et al. Life Sci Alliance. 2018 Dec 6;1(6):e201800237. doi: 10.26508/lsa.201800237. eCollection 2018 Dec. Life Sci Alliance. 2018. PMID: 30564782 Free PMC article.
Upon sensing LPS, caspase-11 assembles a higher order structure called the non-canonical inflammasome that enables the activation of caspase-11 protease function, leading to gasdermin D cleavage and cell death. ...We further …
Upon sensing LPS, caspase-11 assembles a higher order structure called the non-canonical inflammasome that enabl …
Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease.
Yuan YY, Xie KX, Wang SL, Yuan LW. Yuan YY, et al. Gastroenterol Rep (Oxf). 2018 Aug;6(3):167-176. doi: 10.1093/gastro/goy011. Epub 2018 May 2. Gastroenterol Rep (Oxf). 2018. PMID: 30151200 Free PMC article. Review.
Inflammatory programmed cell death is classified as canonical or non-canonical based on inflammatory caspases, which includes caspase-1 (in human and mouse) and caspase-11 (in mouse) or caspase-4 and -5 (in humans). Activated infla …
Inflammatory programmed cell death is classified as canonical or non-canonical based on inflammatory caspases, which in …
Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.
Fender AC, Kleeschulte S, Stolte S, Leineweber K, Kamler M, Bode J, Li N, Dobrev D. Fender AC, et al. Basic Res Cardiol. 2020 Jan 7;115(2):10. doi: 10.1007/s00395-019-0771-9. Basic Res Cardiol. 2020. PMID: 31912235
Caspase-11 activation, which mediates non-canonical NLRP3 inflammasome signaling, was not augmented. Formation of the plasma membrane pore-forming protein N-terminal gasdermin D (GDSMD), a prerequisite for IL-1β secretion, was also higher
Caspase-11 activation, which mediates non-canonical NLRP3 inflammasome signaling, was not augmented. Formation o
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