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The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis in murine macrophages.
Palma C, Iona E, Ebensen T, Guzman CA, Cassone A. Palma C, et al. Among authors: cassone a. Open Microbiol J. 2009 Apr 3;3:47-52. doi: 10.2174/1874285800903010047. Open Microbiol J. 2009. PMID: 19471610 Free PMC article.
We found that a synthetic derivative of the TLR2/6 agonist MALP-2 and the potent TLR4 agonist lipopolysaccharide inhibited the intracellular growth of MTB in murine macrophages. ...
We found that a synthetic derivative of the TLR2/6 agonist MALP-2 and the potent TLR4 agonist lipopolysaccharide inhibited the intrac …
A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine.
Sandini S, La Valle R, Deaglio S, Malavasi F, Cassone A, De Bernardis F. Sandini S, et al. Among authors: cassone a. FEMS Immunol Med Microbiol. 2011 Jul;62(2):215-24. doi: 10.1111/j.1574-695X.2011.00802.x. Epub 2011 Apr 28. FEMS Immunol Med Microbiol. 2011. PMID: 21535228
Sap2 (secreted aspartyl proteinase2) is a member of the Sap family of Candida albicans, a human opportunistic pathogen, which acts as a virulence factor in experimental animal models of mucosal candidiasis. ...Hence, this new recombinant proteinase constitute …
Sap2 (secreted aspartyl proteinase2) is a member of the Sap family of Candida albicans, a human opportunistic pathogen, which …
Isolation, acid proteinase secretion, and experimental pathogenicity of Candida parapsilosis from outpatients with vaginitis.
De Bernardis F, Lorenzini R, Verticchio R, Agatensi L, Cassone A. De Bernardis F, et al. Among authors: cassone a. J Clin Microbiol. 1989 Nov;27(11):2598-603. doi: 10.1128/JCM.27.11.2598-2603.1989. J Clin Microbiol. 1989. PMID: 2681258 Free PMC article.
Candida parapsilosis was isolated from the vaginas of several nonpregnant, nondiabetic, mostly premenopausal outpatients who presented the characteristic signs and symptoms of a frank vulvovaginal candidiasis (heavy discharge with cottage cheese appearance and intense itch …
Candida parapsilosis was isolated from the vaginas of several nonpregnant, nondiabetic, mostly premenopausal outpatients who presented the c …
High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women.
de Bernardis F, Mondello F, Scaravelli G, Pachì A, Girolamo A, Agatensi L, Cassone A. de Bernardis F, et al. Among authors: cassone a. J Clin Microbiol. 1999 May;37(5):1376-80. doi: 10.1128/JCM.37.5.1376-1380.1999. J Clin Microbiol. 1999. PMID: 10203490 Free PMC article.
In an estrogen-dependent, rat vaginitis model, a strain of C. albicans producing a high level of Sap that was isolated from an HIV+ woman with vaginitis was more pathogenic than a strain of C. albicans that was isolated primarily from an HIV-, Candida carrier …
In an estrogen-dependent, rat vaginitis model, a strain of C. albicans producing a high level of Sap that was isolated from an …
Suckling CD1 mice as an animal model for studies of Legionella pneumophila virulence.
Pastoris MC, Proietti E, Mauri C, Chiani P, Cassone A. Pastoris MC, et al. Among authors: cassone a. J Med Microbiol. 1997 Aug;46(8):647-55. doi: 10.1099/00222615-46-8-647. J Med Microbiol. 1997. PMID: 9511812
For example, intraperitoneal inoculation of 10(7) cells of a fresh clinical isolate of L. pneumophila (strain Monza 3) caused 60% mortality of suckling mice in 1 day whereas the same number of cells of a culture-attenuated derivative (strain Monza 3p50) caused<10 …
For example, intraperitoneal inoculation of 10(7) cells of a fresh clinical isolate of L. pneumophila (strain Monza 3) caused 60% mor …
Biotyping and virulence properties of skin isolates of Candida parapsilosis.
De Bernardis F, Mondello F, San Millàn R, Pontòn J, Cassone A. De Bernardis F, et al. Among authors: cassone a. J Clin Microbiol. 1999 Nov;37(11):3481-6. doi: 10.1128/JCM.37.11.3481-3486.1999. J Clin Microbiol. 1999. PMID: 10523538 Free PMC article.
They were also highly vaginopathic in a rat vaginitis model, being significantly more virulent than blood isolates in this infection model. ...Finally, skin isolates did not differ, as a whole, from blood isolates in their adherence to plastic. This property was ass …
They were also highly vaginopathic in a rat vaginitis model, being significantly more virulent than blood isolates in this infection …
Use of a monoclonal antibody in a dot immunobinding assay for detection of a circulating mannoprotein of Candida spp. in neutropenic patients with invasive candidiasis.
De Bernardis F, Girmenia C, Boccanera M, Adriani D, Martino P, Cassone A. De Bernardis F, et al. Among authors: cassone a. J Clin Microbiol. 1993 Dec;31(12):3142-6. doi: 10.1128/JCM.31.12.3142-3146.1993. J Clin Microbiol. 1993. PMID: 8308105 Free PMC article.
A dot immunobinding assay for the detection of a circulating mannoprotein (MP) antigen of Candida species in the sera of neutropenic patients in a hematological setting is described. The technique is based on the use of a monoclonal antibody which reco
A dot immunobinding assay for the detection of a circulating mannoprotein (MP) antigen of Candida species in the sera of neutr
Production and characterisation of a monoclonal antibody to a cell-surface, glucomannoprotein constituent of Candida albicans and other pathogenic Candida species.
Cassone A, Torosantucci A, Boccanera M, Pellegrini G, Palma C, Malavasi F. Cassone A, et al. J Med Microbiol. 1988 Dec;27(4):233-8. doi: 10.1099/00222615-27-4-233. J Med Microbiol. 1988. PMID: 2462051
A murine monoclonal antibody (MAB AF-1) class IgM was raised to a soluble glucomannoprotein extract (GMP) of Candida albicans. Agglutination and indirect immunofluorescence assays with purified MAB showed that AF-1 was directed against a cell-surface epitope
A murine monoclonal antibody (MAB AF-1) class IgM was raised to a soluble glucomannoprotein extract (GMP) of Candida albicans.
Anticandidal activity and interleukin-1 beta and interleukin-6 production by polymorphonuclear leukocytes are preserved in subjects with AIDS.
Cassone A, Palma C, Djeu JY, Aiuti F, Quinti I. Cassone A, et al. J Clin Microbiol. 1993 May;31(5):1354-7. doi: 10.1128/JCM.31.5.1354-1357.1993. J Clin Microbiol. 1993. PMID: 8501241 Free PMC article.
On exposure to granulocyte macrophage-colony-stimulating factor or to a mannoprotein constituent (MP-F2) from C. albicans itself, PMN from AIDS patients showed enhanced antifungal activity and production of remarkable quantities of IL-1 beta and IL-6. ...
On exposure to granulocyte macrophage-colony-stimulating factor or to a mannoprotein constituent (MP-F2) from C. albicans itself, PMN …
Differences in the antigenic expression of immunomodulatory mannoprotein constituents on yeast and mycelial forms of Candida albicans.
Torosantucci A, Boccanera M, Casalinuovo I, Pellegrini G, Cassone A. Torosantucci A, et al. Among authors: cassone a. J Gen Microbiol. 1990 Jul;136(7):1421-8. doi: 10.1099/00221287-136-7-1421. J Gen Microbiol. 1990. PMID: 1700063
This modulation was shared by a number of strains of C. albicans, and was not solely a temperature- or nutrition-dependent phenomenon. ...Irrespective of their source (yeast or mycelial), all fractions reacted to a similar extent with a polyclonal anti …
This modulation was shared by a number of strains of C. albicans, and was not solely a temperature- or nutrition-dependent phe …
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