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WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J. Chávez-Canales M, et al. Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11. Hypertension. 2014. PMID: 25113964 Free PMC article.
SPAKling insight into blood pressure regulation.
Castañeda-Bueno M, Gamba G. Castañeda-Bueno M, et al. EMBO Mol Med. 2010 Feb;2(2):39-41. doi: 10.1002/emmm.200900059. EMBO Mol Med. 2010. PMID: 20112249 Free PMC article.
A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters.
Castañeda-Bueno M, Vázquez N, Bustos-Jaimes I, Hernández D, Rodríguez-Lobato E, Pacheco-Alvarez D, Cariño-Cortés R, Moreno E, Bobadilla NA, Gamba G. Castañeda-Bueno M, et al. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1111-9. doi: 10.1152/ajprenal.00412.2010. Epub 2010 Aug 18. Am J Physiol Renal Physiol. 2010. PMID: 20719978 Free PMC article.
Independent regulation of Na+ and K+ balance by the kidney.
Castañeda-Bueno M, Arroyo JP, Gamba G. Castañeda-Bueno M, et al. Med Princ Pract. 2012;21(2):101-14. doi: 10.1159/000332580. Epub 2011 Oct 25. Med Princ Pract. 2012. PMID: 22042004 Free article. Review.
Insulin increases the functional activity of the renal NaCl cotransporter.
Chávez-Canales M, Arroyo JP, Ko B, Vázquez N, Bautista R, Castañeda-Bueno M, Bobadilla NA, Hoover RS, Gamba G. Chávez-Canales M, et al. J Hypertens. 2013 Feb;31(2):303-11. doi: 10.1097/HJH.0b013e32835bbb83. J Hypertens. 2013. PMID: 23303355 Free PMC article.
Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.
Melo Z, Cruz-Rangel S, Bautista R, Vázquez N, Castañeda-Bueno M, Mount DB, Pasantes-Morales H, Mercado A, Gamba G. Melo Z, et al. Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1402-11. doi: 10.1152/ajprenal.00390.2013. Epub 2013 Oct 2. Am J Physiol Renal Physiol. 2013. PMID: 24089410 Free PMC article.
44 results